ArticleThe Journal of cell biology2014
ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Specialized high-capacity mitochondria fuel cell invasion.Current biology : CB · 2026Article
- The regenerative period of somatosensory nerves is closed by a DCC signaling axis.PLoS genetics · 2026Article
- A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell.Development (Cambridge, England) · 2024Article
- The C. elegans anchor cell: A model to elucidate mechanisms underlying invasion through basement membrane.Seminars in cell & developmental biology · 2024Review
- Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion.Developmental cell · 2022Article
- The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.PLoS genetics · 2022Article
- Reciprocal EGFR signaling in the anchor cell ensures precise inter-organ connection during Caenorhabditis elegans vulval morphogenesis.Development (Cambridge, England) · 2022Article
- RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling.The Journal of cell biology · 2021Article
- Forces drive basement membrane invasion inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling.The EMBO journal · 2018Article
- Cytoskeleton-Associated Risk Modifiers Involved in Early and Rapid Progression of Sporadic Creutzfeldt-Jakob Disease.Molecular neurobiology · 2018Article
- Invading, Leading and Navigating Cells inGenetics · 2018Review
- Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.Nature communications · 2017Article
- Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.The Journal of cell biology · 2017Article
- Breaking down barriers: the evolution of cell invasion.Current opinion in genetics & development · 2017Review
- Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain.Developmental cell · 2017Article
- Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans.Nature protocols · 2017Article
- Divide or Conquer: Cell Cycle Regulation of Invasive Behavior.Trends in cell biology · 2017Review
- A new front in cell invasion: The invadopodial membrane.European journal of cell biology · 2016Review
- LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Invadopodia are protrusive, F-actin-driven membrane structures that are thought to mediate basement membrane transmigration during development and tumor dissemination. An understanding of the mechanisms regulating invadopodia has been hindered by the difficulty of examining these dynamic structures in native environments. Using an RNAi screen and live-cell imaging of anchor cell (AC) invasion in Caenorhabditis elegans, we have identified UNC-60A (ADF/cofilin) as an essential regulator of invadopodia. UNC-60A localizes to AC invadopodia, and its loss resulted in a dramatic slowing of F-actin dynamics and an inability to breach basement membrane. Optical highlighting indicated that UNC-60A disassembles actin filaments at invadopodia. Surprisingly, loss of unc-60a led to the accumulation of invadopodial membrane and associated components within the endolysosomal compartment. Photobleaching experiments revealed that during normal invasion the invadopodial membrane undergoes rapid recycling through the endolysosome. Together, these results identify the invadopodial membrane as a specialized compartment whose recycling to form dynamic, functional invadopodia is dependent on localized F-actin disassembly by ADF/cofilin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.