Evidence map›Paper›PMID 24662368›Full record

ReviewNeurobiology of disease2014

Sex and the migraine brain.

D Borsook, N Erpelding, A Lebel, C Linnman, R Veggeberg, P E Grant, C Buettner, L Becerra, R Burstein

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Hypothalamic and sex-related hormones in migraine.The journal of headache and pain · 2026
    Review
  4. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Women in Dental Clinical and Translational Research.Advances in dental research · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D BorsookBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Massachusestts General Hospital, Boston Children's Hospital, USA; Harvard Medical School, USA. Electronic address: david.borsook@childrens.harvard.edu.
N ErpeldingBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Harvard Medical School, USA.
A LebelBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Headache Clinic, Boston Children's Hospital, USA; Harvard Medical School, USA.
C LinnmanBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Massachusestts General Hospital, Boston Children's Hospital, USA; Harvard Medical School, USA.
R VeggebergBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Harvard Medical School, USA.
P E GrantFetal-Neonatal Neuroimaging and Developmental Science Center (FNNDSC), Boston Children's Hospital, USA; Harvard Medical School, USA.
C BuettnerDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, USA; Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, USA; Harvard Medical School, USA.
L BecerraBoston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Massachusestts General Hospital, Boston Children's Hospital, USA; Harvard Medical School, USA.
R BursteinHarvard Medical School, USA.

Funding

Photophobia during migraine: sensory, autonomic and emotional responses to lightR37NS079678 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BURSTEIN, RAMI · 2012 to 2018
$3.1M
Multimodal Brain Measures of Migraine with Age: Prepuberty to AdultR01NS075018 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI BORSOOK, DAVID · 2012 to 2016
$2.4M
Brain Markers of Low and High Frequency Episodic MigraineR01NS073997 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2011 to 2015
$2.0M
Migraine pathophysiology: neural basis of photophobiaR01NS069847 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BURSTEIN, RAMI · 2010 to 2014
$1.9M
Imaging Pain and Analgesia: Mentoring in Basic and Applied ResearchK24NS064050 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2008 to 2017
$1.7M
fMRI Measures of Central Sensitization in MigraineR01NS056195 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2006 to 2010
$1.7M
Molecular and Functional PET-fMRI Measures of Placebo Analgesia in MigraineR21AT007530 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI BORSOOK, DAVID · 2012 to 2013
$468k
NCCIH NIH HHS R21 AT007530NCCIH NIH HHS R21AT007530NINDS NIH HHS K24 NS064050NINDS NIH HHS K24NS064050NINDS NIH HHS R01 NS056195NINDS NIH HHS R01NS056195NINDS NIH HHS R01 NS069847NINDS NIH HHS R01NS069847NINDS NIH HHS R01 NS073997NINDS NIH HHS R01NS073997NINDS NIH HHS R01 NS075018NINDS NIH HHS R37 NS079678NINDS NIH HHS R37NS079678
6 · The paper itself

Abstract

The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.

Indexed as

AnimalsBrainEstrogensFemaleHumansMaleMigraine DisordersSex FactorsEstrogensAllostatic loadCortical spreading depressionEstrogenGonadotrophinsHeadacheHypothalamusMenstrual cyclePainProgesteronePubertySleepTrigeminalWomen

Identifiers

PMID24662368
PMCPMC4171725

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.