Evidence map›Paper›PMID 24662221›Full record

ReviewNature reviews. Genetics2014

Genomic insights into tuberculosis.

James E Galagan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Journal of bacteriology · 2026
    Review
  8. Article
  9. Review
  10. First report of whole genome sequence of a Mycobacterium bovis (3/86Rv) strain isolated from a cow in India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. CD4Immunity · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Diversification of gene content in theMicrobiology spectrum · 2024
    Article
  19. Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James E GalaganDepartment of Biomedical Engineering, Bioinformatics program and National Emerging Infectious Diseases Laboratory, Boston University, 34 Cummington Mall 1002, Boston, Massachusetts 02215; and Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Funding

PHS HHS HHSN272200800059C
6 · The paper itself

Abstract

Prevalent since pre-history, human tuberculosis - caused by the pathogen Mycobacterium tuberculosis - remains a major source of death worldwide. Moreover, increasing drug resistance poses the threat of disease resurgence. However, the expanding application of genomic techniques is providing new avenues for combating this old foe. Whole-genome sequencing, comparative genomics and systems biology are generating new insights into the origins and ongoing evolution of M. tuberculosis, as well as the molecular basis for its pathogenicity. These have important implications for our perspective of the disease, development of new drugs and vaccines, and treatment of patients using existing therapeutics.

Indexed as

GenomicsDrug Resistance, Multiple, BacterialEvolution, MolecularGenome, BacterialHumansMolecular EpidemiologyMycobacterium tuberculosisPhylogenySystems BiologyTuberculosis

Identifiers

PMID24662221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.