ReviewNeuroscience and biobehavioral reviews2014
The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic.
Review in Neuroscience and biobehavioral reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review.Acta neuropsychiatrica · 2024Pooled it
- Fear Circuits in Panic Disorder: An Update.Alpha psychiatry · 2025Review
- Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder.Scientific reports · 2025Article
- Sex-specific threat responding and neuronal engagement in carbon dioxide associated fear and extinction: Noradrenergic involvement in female mice.Neurobiology of stress · 2024Article
- Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms.ACS chemical neuroscience · 2024Article
- The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions.Frontiers in neuroscience · 2024Review
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- Fish personality: meta-theoretical issues, personality dimensions, and applications to neuroscience and psychopathology.Personality neuroscience · 2023Review
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Neuropathological Changes in the Brains of Suicide Killers.Biomolecules · 2021Article
- The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena.Neuroscience bulletin · 2021Review
- Panic and pandemic: Narrative review of the literature on the links and risks of panic disorder as a consequence of the SARS-CoV-2 pandemic.L'Encephale · 2021Review
- Experimental Drugs for Panic Disorder: An Updated Systematic Review.Journal of experimental pharmacology · 2021Review
- Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- [Panic and pandemic: Review of the literature on the links between panic disorder and the SARS-CoV-2 epidemic].L'Encephale · 2020Review
- Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats.Behavioural brain research · 2020Article
- Activity of a vmPFC-DRN Pathway Corresponds With Resistance to Acute Social Defeat Stress.Frontiers in neural circuits · 2020Article
- A Shift in the Activation of Serotonergic and Non-serotonergic Neurons in the Dorsal Raphe Lateral Wings Subnucleus Underlies the Panicolytic-Like Effect of Fluoxetine in Rats.Molecular neurobiology · 2019Article
- The Parable of Panic: Suffocation, Social Attachment, and the Critical Role of an Integrative, Biopsychosocial Formulation.Biological psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The Deakin/Graeff hypothesis proposes that different subpopulations of serotonergic neurons through topographically organized projections to forebrain and brainstem structures modulate the response to acute and chronic stressors, and that dysfunction of these neurons increases vulnerability to affective and anxiety disorders, including panic disorder. We outline evidence supporting the existence of a serotonergic system originally discussed by Deakin/Graeff that is implicated in the inhibition of panic-like behavioral and physiological responses. Evidence supporting this panic inhibition system comes from the following observations: (1) serotonergic neurons located in the 'ventrolateral dorsal raphe nucleus' (DRVL) as well as the ventrolateral periaqueductal gray (VLPAG) inhibit dorsal periaqueductal gray-elicited panic-like responses; (2) chronic, but not acute, antidepressant treatment potentiates serotonin's panicolytic effect; (3) contextual fear activates a central nucleus of the amygdala-DRVL/VLPAG circuit implicated in mediating freezing and inhibiting panic-like escape behaviors; (4) DRVL/VLPAG serotonergic neurons are central chemoreceptors and modulate the behavioral and cardiorespiratory response to panicogenic agents such as sodium lactate and CO2. Implications of the panic inhibition system are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.