ArticleJournal of diabetes and its complications
The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy.
Article in Journal of diabetes and its complications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients
Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care.
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Pooled it
- Sudomotor function testing by electrochemical skin conductance: does it really measure sudomotor function?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Pooled it
- Sudomotor dysfunction as a measure of small fiber neuropathy in type 1 diabetes.Autonomic neuroscience : basic & clinical · 2017Trial
- Comparing the Diagnostic Characteristics of Neuropathy Questionnaires in Adults With Obesity.Journal of the peripheral nervous system : JPNS · 2026Article
- Sudomotor dysfunction in people with type 1 diabetes with and without clinical peripheral neuropathy: A study from Pune, India.Journal of diabetes investigation · 2026Article
- Skin Lesions in Diabetes Mellitus: A 6-Year Observational Study and 11-Year Longitudinal Analysis of Hospital Admissions from NE Romania.Life (Basel, Switzerland) · 2026Article
- Clinical, Neuropathic, and Sudomotor Correlates of Orthostatic Hypotension in Type 2 Diabetes: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The importance of hair in human perception of electric fields - A double-blind repeated measures study.Scientific reports · 2026Article
- Sudoscan® and QSART in the composite autonomic severity scale: complementary approaches to sudomotor assessment in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Predictors of Peripheral Neuropathy in Metabolic Disease: A Multivariable Analysis Incorporating the Toronto Clinical Scoring System and Sudomotor Assessment.Medicina (Kaunas, Lithuania) · 2026Article
- Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment.Journal of diabetes investigation · 2026Article
- Serum Uric Acid-to-Creatinine Ratio Is Independently Associated with Sudomotor Dysfunction in Type 2 Diabetes: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Diabetic Peripheral Neuropathy: Current Epidemiology, Diagnostic Advances, Biomarkers, and Management Strategies.Journal of diabetes research · 2026Review
- Article
- Association between insulin resistance and sudomotor dysfunction in adults with type 1 diabetes.Endocrine connections · 2025Article
- Review
- Sudomotor Dysfunction of Feet Is Associated with Cardiac Autonomic Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- A new screening tool for early recognition of ATTRv polyneuropathy in clinical practice: AmyloScanJournal of neurology · 2025Article
- Diagnostic advancements in early detection of diabetic neuropathy: comparative analysis of medial and lateral plantar nerve degeneration.Annals of medicine and surgery (2012) · 2025Review
- Sudomotor Dysfunction as an Early Marker of Autonomic and Cardiovascular Risk in Diabetes: Insights from a Cross-Sectional Study Using SUDOSCAN.Biosensors · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimsDiagnosis of early distal symmetric polyneuropathy (DSP) is challenging. Nerve conduction studies (NCS) are often normal. Skin biopsy for intraepidermal nerve fiber density (IENFD) has better sensitivity, but is invasive. Sudoscan is a novel technology that measures electrochemical skin conductance (ESC; microSiemens, μS), which is thought to be proportionate to the number of functional sweat glands. This study evaluated Sudoscan's diagnostic utility for DSP.
methods55 patients with suspected DSP (22 with diabetes, 2 prediabetes, 31 idiopathic) and 42 controls underwent the Utah Early Neuropathy Scale (UENS) and Sudoscan. Each was offered skin biopsy. DSP participants underwent quantitative sudomotor axon reflex testing (QSART) and NCS.
resultsFeet and hands ESCs were reduced among DSP participants compared to controls (64±22 vs. 76±14 μS p<0.005, and 58±19 vs. 66±18 μS p<0.04). There was no difference between diabetic and idiopathic DSP. Receiver operating characteristic curve analysis revealed feet ESC and IENFD had similar areas under the curve (0.761 and 0.752). ESC correlated with Sural amplitude (0.337, p<0.02), UENS (-0.388, p<0.004), and MNSI (-0.398, p<0.005).
conclusionsSudoscan is a promising diagnostic test for diabetic and idiopathic DSP, with diagnostic performance similar to IENFD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.