ArticleAging cell2014
Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring.
Article in Aging cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Maternal effect senescence and caloric restriction interact to affect fitness through changes in life history timing.The Journal of animal ecology · 2025Article
- Response of fruit fly (Physiological entomology · 2024Article
- Maternal age effects on offspring lifespan and reproduction vary within a species.Ecology and evolution · 2024Article
- The Contributions of Maternal Age Heterogeneity to Variance in Lifetime Reproductive Output.The American naturalist · 2022Article
- A demographic and evolutionary analysis of maternal effect senescence.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines.PLoS biology · 2019Article
- Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction.Scientific reports · 2019Article
- Aging extension and modifications of lipid metabolism in the monogonont rotifer Brachionus koreanus under chronic caloric restriction.Scientific reports · 2018Article
- Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system.BMC genomics · 2017Article
- Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions.Journal of visualized experiments : JoVE · 2016Article
- Article
- Plasticity and regeneration of gonads in the annelidEvoDevo · 2016Article
- Rotifers as experimental tools for investigating aging.Invertebrate reproduction & development · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
While many studies have focused on the detrimental effects of advanced maternal age and harmful prenatal environments on progeny, little is known about the role of beneficial non-Mendelian maternal inheritance on aging. Here, we report the effects of maternal age and maternal caloric restriction (CR) on the life span and health span of offspring for a clonal culture of the monogonont rotifer Brachionus manjavacas. Mothers on regimens of chronic CR (CCR) or intermittent fasting (IF) had increased life span compared with mothers fed ad libitum (AL). With increasing maternal age, life span and fecundity of female offspring of AL-fed mothers decreased significantly and life span of male offspring was unchanged, whereas body size of both male and female offspring increased. Maternal CR partially rescued these effects, increasing the mean life span of AL-fed female offspring but not male offspring and increasing the fecundity of AL-fed female offspring compared with offspring of mothers of the same age. Both maternal CR regimens decreased male offspring body size, but only maternal IF decreased body size of female offspring, whereas maternal CCR caused a slight increase. Understanding the genetic and biochemical basis of these different maternal effects on aging may guide effective interventions to improve health span and life span.
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Registered trials
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