ArticleThe European journal of neuroscience2014
The role of glutamate in the morphological and physiological development of dendritic spines.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice.Brain structure & function · 2025Article
- Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Protein 4.1N Plays a Cell Type-Specific Role in Hippocampal Glutamatergic Synapse Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors.Cell reports · 2022Article
- Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats.Neuroscience and biobehavioral reviews · 2021Review
- Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice.Molecular psychiatry · 2021Article
- Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles.Current research in neurobiology · 2021Article
- Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.Addiction biology · 2020Article
- Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.Frontiers in psychiatry · 2020Article
- The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.Molecular neurobiology · 2019Article
- Klotho deficiency affects the spine morphology and network synchronization of neurons.Molecular and cellular neurosciences · 2019Article
- Article
- Probing the Interplay between Dendritic Spine Morphology and Membrane-Bound Diffusion.Biophysical journal · 2017Article
- Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons.Scientific reports · 2017Article
- Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS · 2017Review
- Structural and functional plasticity of dendritic spines - root or result of behavior?Genes, brain, and behavior · 2017Review
- mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex.CNS & neurological disorders drug targets · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dendritic spines form the postsynaptic half of the synapse but how they form during CNS development remains uncertain, as are the factors that promote their morphological and physiological maturation. One hypothesis posits that filopodia, long motile dendritic processes that are present prior to spine formation, are the precursors to spines. Another hypothesis posits that they form directly from the dendritic shaft. We used microphotolysis of caged glutamate to stimulate individual dendritic processes in young hippocampal slice cultures while recording their morphological and physiological responses. We observed that brief trains of stimuli delivered to immature processes triggered morphological changes within minutes that resulted, in about half of experiments, in a more mature, spine-like appearance such as decreased spine neck length and increased spine head width. We also observed that glutamate-induced inward currents elicited from immature processes were mostly or entirely mediated by NMDARs, whereas responses in those processes with a more mature morphology, regardless of actual developmental age, were mediated by both AMPARs and NMDARs. Consistent with this observation, glutamate-induced morphological changes were largely, but not entirely, prevented by blocking NMDARs. Our observations thus favor a model in which filopodia in the developing nervous system sense and respond to release of glutamate from developing axons, resulting in physiological and morphological maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.