ArticleThe journal of headache and pain2014
Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia.
Article in The journal of headache and pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Pooled it
- Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Pooled it
- Brain Regional Predictors of Surgical Response Are Dynamically Associated with Post-Surgical Pain Relief in Trigeminal Neuralgia.Brain sciences · 2026Article
- Article
- Stress-related white matter microstructure alterations and chronic pain.Brain imaging and behavior · 2026Article
- Pain-side-specific alteration of structural networks in trigeminal neuralgia: a connectome analysis.Frontiers in neuroscience · 2026Article
- Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis.Brain communications · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.Communications biology · 2025Article
- Assessing the impact of fetal growth restriction using high-resolution MRI: a comprehensive cortical analysis.BMC pregnancy and childbirth · 2025Article
- Structural alterations in occipital cortices in trigeminal neuralgia: a voxel- and surface-based morphometric MRI study.The journal of headache and pain · 2025Article
- The relationship between regional homogeneity in resting-state functional magnetic resonance imaging and cognitive function in depressive disorders with migraine.Scientific reports · 2025Article
- Amplitude of low-frequency fluctuations in classical trigeminal neuralgia patients with purely paroxysmal and concomitant continuous pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Altered spontaneous brain activity in patients with progressive-stage and end-stage chronic kidney disease: insights from dALFF analysis.Metabolic brain disease · 2024Article
- Distinctive cortical morphological patterns in primary trigeminal neuralgia: a cross-sectional clinical study.Neuroradiology · 2024Observational
- White and Gray Matter Abnormalities in Young Adult Females with Dependent Personality Disorder: A Diffusion-Tensor Imaging and Voxel-Based Morphometry Study.Brain topography · 2024Article
- Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI.The journal of headache and pain · 2023Article
- Frequency-Dependent Alterations in the Amplitude of Low-Frequency Fluctuations in Patients with Acute Pericoronitis: A Resting-State fMRI Study.Journal of pain research · 2023Article
- Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study.Frontiers in human neuroscience · 2023Article
- A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN).
methodsThe aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); and cortical thickness changes with surface based morphometry. Twenty-four patients with classical TN (37-67 y-o) and 24 healthy controls, matched for age and sex, were included in the study.
resultsComparing patients with controls, no diffusivity abnormalities of brain white matter were detected. However, a significant reduction in cortical thickness was observed at the left cuneus and left fusiform cortex in the patients group. The thickness of the fusiform cortex correlated negatively with the carbamazepine dose (p = 0.023).
conclusionsSince the cuneus and the fusiform gyrus have been related to the multisensory integration area and cognitive processing, as well as the retrieval of shock perception conveyed by Aδ fibers, our results support the role of these areas in TN pathogenesis. Whether such changes occurs as an epiphenomenon secondary to daily stimulation or represent a structural predisposition to TN in the light of peripheral vascular compression is a matter of future studies.
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