ArticleRadiation oncology (London, England)2014
IMRT with ¹⁸FDG-PET\CT based simultaneous integrated boost for treatment of nodal positive cervical cancer.
Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04016142 (Phase II Trial of Weekly Carboplatin-Paclitaxel Adjuvant Chemotherapy After Intensity Modulated Extended-field Chemoradiation in the Treatment of Locally Advanced Cervical Cancer With Para-aortic Positive Nodes), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II Trial of Weekly Carboplatin-Paclitaxel Adjuvant Chemotherapy After Intensity Modulated Extended-field Chemoradiation in the Treatment of Locally Advanced Cervical Cancer With Para-aortic Positive Nodes
Who cites it
19 citing papers in PubMed.
- Intensity-modulated radiation therapy with the central shielding technique for patients with uterine cervical cancer†.Journal of radiation research · 2023Article
- ESGO/ESTRO quality indicators for radiation therapy of cervical cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Value of tube combined with real-time ultrasound-guided accurate interstitial high-dose-rate brachytherapy for post-operative pelvic side-wall recurrences of cervical cancer.Journal of contemporary brachytherapy · 2021Article
- High dose simultaneous integrated boost for node positive cervical cancer.Radiation oncology (London, England) · 2021Article
- Radiomics for radiation oncologists: are we ready to go?BJR open · 2020Review
- Tolerability, Efficacy and Feasibility of Concurrent Gemcitabine and Cisplatin (CGP) Combined With Intensity Modulated Radiotherapy for Loco-Regionally Advanced Carcinoma of the Cervix.Journal of Cancer · 2020Article
- Positron emission tomography for staging locally advanced cervical cancer and assessing intensity modulated radiotherapy approach.La Radiologia medica · 2019Article
- Intensity Modulated Radiation Therapy and Image-Guided Adapted Brachytherapy for Cervix Cancer.International journal of radiation oncology, biology, physics · 2019Article
- Efficacy and Toxicity of IMRT-Based Simultaneous Integrated Boost for the Definitive Management of Positive Lymph Nodes in Patients with Cervical Cancer.Journal of Cancer · 2019Article
- Clinical Impact ofAsia Oceania journal of nuclear medicine & biology · 2019Article
- Evaluating the Use of 18F-FDG PET CT for External Beam Radiotherapy Planning in Gynaecological Malignancies.Current oncology reports · 2018Review
- Highly conformal combined radiotherapy with cisplatin and gemcitabine for treatment of loco-regionally advanced cervical cancer - a retrospective study.Radiation oncology (London, England) · 2017Article
- Simultaneously integrated boost (SIB) spares OAR and reduces treatment time in locally advanced cervical cancer.Journal of applied clinical medical physics · 2016Article
- Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database.Radiation oncology (London, England) · 2016Article
- Short-course PET based simultaneous integrated boost for locally advanced cervical cancer.Radiation oncology (London, England) · 2016Article
- Dose escalated intensity modulated radiotherapy in the treatment of cervical cancer.Radiation oncology (London, England) · 2015Article
- Distribution pattern of lymph node metastases and its implication in individualized radiotherapeutic clinical target volume delineation of regional lymph nodes in patients with stage IA to IIA cervical cancer.Radiation oncology (London, England) · 2015Article
- Use of Specific Duodenal Dose Constraints During Treatment Planning Reduces Toxicity After Definitive Paraaortic Radiation Therapy for Cervical Cancer.Practical radiation oncologyArticle
- A novel dynamic field-matching technique for treatment of patients with para-aortic node-positive cervical cancer: Clinical experience.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
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6 authors.
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Abstract
backgroundTo evaluate toxicity and outcome of intensity modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) to the positive lymph nodes in patients with loco-regional advanced cervical cancer (LRACC).
methodsThe study population comprised ten patients with 18FDG-PET\CT positive lymph nodes (LNs), who underwent chemoradiation with IMRT and SIB. A dose of 50.4 Gy, in daily fractions of 1.8 Gy, was delivered to primary tumor and draining LNs. Primary tumor received an additional external beam boost to a total dose of 55.8 Gy. A SIB of 62 Gy, in daily fractions of 2 Gy, was delivered to the 18FDG-PET\CT positive LNs. Finally, a high dose rate brachytherapy (HDRB) boost (15 - 18 Gy) was administered to the primary tumor. The primary goal of this study was to evaluate acute and early late toxicity and loco-regional control.
resultsThe median number of irradiated LNs per patient was 3 (range: 1-6) with a median middle nodal SIB-volume of 26.10 cm3 (range, 11.9-82.50 cm3). Median follow-up was 20 months (range, 12 to 30 months). Acute and late grade 3 toxicity was observed in 1 patient. Three of the patients developed a recurrence, one in the form of a local tumor relapse, one had a paraaortic LN metastasis outside the treated volume and the last one developed a distant metastasis.
conclusionIMRT with SIB in the region of 18FDG-PET positive lymph nodes appears to be an effective therapy with acceptable toxicity and might be useful in the treatment of patients with locally advanced cervical cancer.
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