ArticleLipids in health and disease2014
Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population.
Article in Lipids in health and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study.Molecular neurobiology · 2016Pooled it
- The Influence of OLR1 and PCSK9 Gene Polymorphisms on Ischemic Stroke: Evidence from a Meta-Analysis.Scientific reports · 2015Pooled it
- Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke.Translational stroke research · 2025Review
- Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.Frontiers in neurology · 2025Article
- LOX-1 variants modulate the severity of cardiovascular disease: state of the art and future directions.Molecular and cellular biochemistry · 2024Review
- Effects of BDNF-Transfected BMSCs on Neural Functional Recovery and Synaptophysin Expression in Rats with Cerebral Infarction.Molecular neurobiology · 2017Article
- Association of the LOX-1 rs1050283 Polymorphism with Risk for Atherosclerotic Cerebral Infarction and its Effect on sLOX-1 and LOX-1 Expression in a Chinese Population.Journal of atherosclerosis and thrombosis · 2017Article
- LOX-1 in Ischemic Stroke.Journal of atherosclerosis and thrombosis · 2017Article
- Upregulation of OLR1 and IL17A genes and their association with blood glucose and lipid levels in femoropopliteal artery disease.Experimental and therapeutic medicine · 2017Article
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4 authors.
Funding
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Abstract
backgroundLectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3'-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.
methodsA total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3'-UTR-C188T and G501C, were analyzed by polymerase chain reaction-ligation detection reaction method.
resultsThe frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3'-UTR-C188T and cerebral infarction.
conclusionsThe study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.
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