Evidence map›Paper›PMID 24661306›Full record

SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2014

Enhanced recovery following liver surgery: a systematic review and meta-analysis.

Michael J Hughes, Stephen McNally, Stephen J Wigmore

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02647047 (Spinal Analgesia Versus Epidural Analgesia in Minor Laparotomic Liver Surgery in an Enhanced Recovery Programme), which is not on this map. Cited by 76 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 15 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02647047 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Spinal Analgesia Versus Epidural Analgesia in Minor Laparotomic Liver Surgery in an Enhanced Recovery Programme: A Randomized Controlled Trial

TypeinterventionalSponsorOspedale San RaffaeleRan2016 to 2016Enrolled40ConditionsSecondary Malignant Neoplasm of Liver, Liver Diseases, Liver NeoplasmsArmsSpinal analgesia, Epidural analgesia, Transversus Abdominis Plane block, Surgical wound infiltration, Acetaminophen
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 15 syntheses or guidelines pooled it, 182 citations in OpenAlex.

  1. Pooled it
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  3. [Enhanced recovery after surgery-Does the ERAS concept keep its promises].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
    Pooled it
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  5. Enhanced Recovery After Surgery (ERAS) Reduces Hospital Costs and Improve Clinical Outcomes in Liver Surgery: a Systematic Review and Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Pooled it
  6. Pooled it
  7. ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019
    Guideline
  8. Pooled it
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  10. Enhanced Recovery after Surgery Programs for Liver Resection: a Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Pooled it
  11. Pooled it
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  13. Central venous pressure and liver resection: a systematic review and meta-analysis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015
    Pooled it
  14. Fast-Track Programs for Liver Surgery: A Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015
    Pooled it
  15. Pooled it
  16. Trial
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  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael J HughesDepartment of Clinical Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.
Stephen McNally
Stephen J Wigmore
Edinburgh Royal Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) programmes aim to improve postoperative outcomes. They are being utilized increasingly in hepatic surgery. This review aims to evaluate the impact of ERAS programmes on outcomes following liver surgery.

methodsEMBASE, MEDLINE, PubMed and the Cochrane Database were searched for trials comparing outcomes in patients undergoing liver surgery utilizing ERAS principles with those in patients receiving conventional care. The primary outcome was occurrence of postoperative complications within 30 days. Secondary outcomes included length of stay (LoS), functional recovery and adherence to ERAS protocols.

resultsNine articles were included in the review, of which two were randomized controlled trials (RCTs). Overall complication rates were 25.0% (range: 11.5-46.4%) in ERAS patients, and 31.0% (range: 11.8-46.2%) in conventional care patients. Significantly reduced overall complication rates following ERAS care were demonstrated by a meta-analysis of the data reported in the two RCTs (odds ratio: 0.49, 95% confidence interval 0.28-0.84; P = 0.01) The median LoS reported by the studies was 5.0 days (range: 2.5-7.0 days) in ERAS patients, and 7.5 days (range: 3.0-11.0 days) in non-ERAS patients. Recovery milestones, when reported, were improved following ERAS care.

conclusionsThe adoption of ERAS protocols improves morbidity and LoS following liver surgery. Future ERAS programmes should accommodate the unique requirements of liver surgery in order to optimize postoperative outcomes.

Indexed as

Digestive System Surgical ProceduresPostoperative CareChi-Square DistributionClinical ProtocolsHumansLength of StayLiver DiseasesOdds RatioPostoperative ComplicationsRecovery of FunctionRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID24661306
PMCPMC4113251
OpenAlexW2079292549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.