ReviewBritish journal of pharmacology2015
Gas what: NO is not the only answer to sexual function.
Review in British journal of pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Gas signaling molecule: a new research focus in the treatment of erectile dysfunction.Medical gas research · 2027Review
- Exploring the application of shear stress in erectile dysfunction.Asian journal of andrology · 2026Review
- Mechanism of traditional Chinese medicine in treating erectile dysfunction: A review.Medicine · 2026Review
- Measurement of PDE5 concentration in human serum: proof-of-concept and validation of methodology in control and prostate cancer patients.Journal of endocrinological investigation · 2025Article
- Noble Gases Therapy in Cardiocerebrovascular Diseases: The Novel Stars?Frontiers in cardiovascular medicine · 2022Review
- Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.Oxidative medicine and cellular longevity · 2021Review
- Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.Oxidative medicine and cellular longevity · 2020Article
- Cavernosal hydrogen sulfide levels are associated with nitric oxide and hemeoxygenase levels in diabetic rats.International journal of impotence research · 2019Article
- Article
- Mediterranean diet and erectile dysfunction: a current perspective.Central European journal of urology · 2017Article
- Affinin (Spilanthol), Isolated from Heliopsis longipes, Induces Vasodilation via Activation of Gasotransmitters and Prostacyclin Signaling Pathways.International journal of molecular sciences · 2017Article
- A Synthetic Supramolecular Receptor for the Hydrosulfide Anion.Angewandte Chemie (International ed. in English) · 2016Article
- Pharmacology of the 'gasotransmitters' NO, CO and H2S: translational opportunities.British journal of pharmacology · 2015Article
- Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.PloS one · 2015Article
- Safety and efficacy of low intensity shockwave (LISW) treatment in patients with erectile dysfunction.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to get and keep an erection is important to men for several reasons and the inability is known as erectile dysfunction (ED). ED has started to be accepted as an early indicator of systemic endothelial dysfunction and subsequently of cardiovascular diseases. The role of NO in endothelial relaxation and erectile function is well accepted. The discovery of NO as a small signalling gasotransmitter led to the investigation of the role of other endogenously derived gases, carbon monoxide (CO) and hydrogen sulphide (H2 S) in physiological and pathophysiological conditions. The role of NO and CO in sexual function and dysfunction has been investigated more extensively and, recently, the involvement of H2 S in erectile function has also been confirmed. In this review, we focus on the role of these three sister gasotransmitters in the physiology, pharmacology and pathophysiology of sexual function in man, specifically erectile function. We have also reviewed the role of soluble guanylyl cyclase/cGMP pathway as a common target of these gasotransmitters. Several studies have proposed alternative therapies targeting different mechanisms in addition to PDE-5 inhibition for ED treatment, since some patients do not respond to these drugs. This review highlights complementary and possible coordinated roles for these mediators and treatments targeting these gasotransmitters in erectile function/ED.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.