Evidence map›Paper›PMID 24661192›Full record

ArticleBritish journal of clinical pharmacology2014

Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process.

Emily Reeve, Sepehr Shakib, Ivanka Hendrix, Michael S Roberts, Michael D Wiese

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 174 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03283735 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal

TypeinterventionalSponsorUniversity of Beira InteriorRan2019 to 2020Enrolled380ConditionsPolypharmacy, DeprescriptionsArmsElderly Enablement
NCT03354845 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Deprescribing of Symptomatic Medications in Patients Receiving Rehabilitative or Subacute Care

TypeinterventionalSponsorBright Vision HospitalRan2016 to 2018Enrolled200ConditionsPolypharmacy, Adverse Drug ReactionArmsDeprescribing intervention
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  2. Withdrawal of antihypertensive drugs in older people.The Cochrane database of systematic reviews · 2025
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  11. Withdrawal of antihypertensive drugs in older people.The Cochrane database of systematic reviews · 2020
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  13. Effects of discontinuation of chronic medication in primary care: a systematic review of deprescribing trials.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily ReeveSansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia; Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Sepehr Shakib
Ivanka Hendrix
Michael S Roberts
Michael D Wiese

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inappropriate use of medication is widespread, especially in older people, and is associated with risks, including adverse drug reactions, hospitalization and increased mortality. Optimization of appropriate medication use to minimize these harms is an ongoing challenge in healthcare. The term 'deprescribing' has been used to describe the complex process that is required for safe and effective cessation of medication. Patients play an important role in their own health and, while they may complain about the number of medications they have to take, they may also be reluctant to cease a medication when given the opportunity to do so. A review of previously proposed deprescribing processes and relevant literature was used to develop the patient-centred deprescribing process, which is a five-step cycle that encompasses gaining a comprehensive medication history, identifying potentially inappropriate medications, determining whether the potentially inappropriate medication can be ceased, planning the withdrawal regimen (e.g. tapering where necessary) and provision of monitoring, support and documentation. This is the first deprescribing process developed using knowledge of the patients' views of medication cessation; it focuses on engaging patients throughout the process, with the aim of improving long-term health outcomes. Despite a comprehensive review of the literature, there is still a lack in the evidence base on which to conduct deprescribing. The next step in broadening the evidence to support deprescribing will be to test the developed process to determine feasibility in the clinical setting.

Indexed as

Inappropriate PrescribingPatient-Centered CareEvidence-Based PracticeHumansMedication Adherencedeprescribingdeprescribing processelderlyinappropriate medication usemedication withdrawalpolypharmacy

Identifiers

PMID24661192
PMCPMC4239968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.