Evidence map›Paper›PMID 24660851›Full record

ArticleLeukemia & lymphoma2014

Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma.

Hesham M Hassan, Michelle L Varney, Smrati Jain, Dennis D Weisenburger, Rakesh K Singh, Bhavana J Dave

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hesham M HassanDepartment of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE , USA.
Michelle L Varney
Smrati Jain
Dennis D Weisenburger
Rakesh K Singh
Bhavana J Dave
University of Nebraska Medical Center · USCity Of Hope National Medical Center · USNebraska Medical Center · US

Funding

MOLECULAR CLASSIFICATION OF B-CELL LYMPHOMAU01CA084967 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHAN, WING C. · 1999 to 2004
$4.1M
NCI NIH HHS U01 CA084967NCI NIH HHS UO1 CA84967
6 · The paper itself

Abstract

The TP73 gene is located at the chromosome 1p36 locus that is commonly disrupted or deleted in follicular lymphoma (FL) with poor prognosis. Therefore, we analyzed the expression of the pro-apoptotic TAp73 and anti-apoptotic ΔNp73 isoforms in cases of FL with normal or abnormal 1p36. We observed a significant increase in ΔNp73 expression and ΔNp73:TAp73 ratio, lower expression of cleaved caspase-3 and a higher frequency of Ki-67 and proliferating cell nuclear antigen (PCNA) positive cells in cases of FL with abnormal 1p36. A negative correlation between the ΔNp73:TAp73 ratio and cleaved caspase-3 expression, and a positive correlation between ΔNp73 expression and Ki-67 or PCNA, were observed. The expression of TAp73 and its pro-apoptotic transcriptional targets BIM. PUMA and NOXA were significantly lower in FL compared to reactive follicular hyperplasia. Together, our data demonstrate that 1p36 disruption is associated with increased ΔNp73 expression, decreased apoptosis and increased proliferation in FL.

Indexed as

Chromosome AberrationsChromosomes, Human, Pair 1Gene Expression Regulation, NeoplasticGenetic LociApoptosisApoptosis Regulatory ProteinsBcl-2-Like Protein 11Cell ProliferationDNA-Binding ProteinsHumansIn Situ Hybridization, FluorescenceLymphoma, FollicularMembrane ProteinsNuclear ProteinsProtein IsoformsProto-Oncogene ProteinsApoptosis Regulatory ProteinsBBC3 protein, humanBCL2L11 protein, humanBcl-2-Like Protein 11delta Np73 protein, humanDNA-Binding ProteinsMembrane ProteinsNuclear ProteinsPMAIP1 protein, humanProtein IsoformsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TP73 protein, humanTumor Protein p73Tumor Suppressor ProteinsChromosome 1p36follicular lymphomap73 isoforms

Identifiers

PMID24660851
PMCPMC4671500
OpenAlexW2045937953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.