Trial reportEmotion (Washington, D.C.)2014
Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress.
Trial report in Emotion (Washington, D.C.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.Translational psychiatry · 2015Trial
- Deviant Peer Affiliation, Depression, and Adolescent Non-Suicidal Self-Injury: The Moderating Effect of the OXTR Gene rs53576 Polymorphism.Children (Basel, Switzerland) · 2024Article
- Article
- Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.Comprehensive psychoneuroendocrinology · 2023Article
- Advances in human oxytocin measurement: challenges and proposed solutions.Molecular psychiatry · 2023Review
- Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking.Neurobiology of stress · 2021Review
- Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2021Review
- Synchronous caregiving from birth to adulthood tunes humans' social brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level.Heliyon · 2020Article
- Links Between the Neurobiology of Oxytocin and Human Musicality.Frontiers in human neuroscience · 2020Review
- Childhood adversity and parenting behavior: the role of oxytocin receptor gene polymorphisms.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci.Translational psychiatry · 2019Article
- Caring helps: Trait empathy is related to better coping strategies and differs in the poor versus the rich.PloS one · 2019Article
- The AVPR1A Gene and Its Single Nucleotide Polymorphism rs10877969: A Literature Review of Associations with Health Conditions and Pain.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2018Review
- Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers.Frontiers in human neuroscience · 2018Article
- A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2018Review
- Pleiotropic Contribution ofFrontiers in behavioral neuroscience · 2018Article
- Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.Journal of psychiatric research · 2017Article
- Effects of oxytocin administration on spirituality and emotional responses to meditation.Social cognitive and affective neuroscience · 2016Article
- Oxytocin and parent-child interaction in the development of empathy among children at risk for autism.Developmental psychology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Oxytocin (OT) and a polymorphism (rs53576) in the oxytocin receptor gene (OXTR) have been independently associated with stress reactivity, whereas oxytocin's sister peptide, arginine vasopressin (AVP) and polymorphisms in the vasopressin receptor gene (AVPR1A) have been independently associated with aggressive behavior. In this study, 68 men and 98 women were genotyped for the OXTR rs53576 polymorphism and the AVPR1A RS1 polymorphism. Baseline and poststressor levels of plasma OT, plasma AVP, positive affect, and anger were assessed. Women, but not men, with high levels of poststressor OT and the GG genotype of rs53576 felt the most positive affect after the stressor. Men, but not women, with high levels of poststressor AVP and the 320 allele of the RS1 polymorphism reported more poststressor anger than noncarriers. These data constitute the first evidence that oxytocin and vasopressin receptor genes interact with levels of OT and AVP to predict sex-specific emotional stress responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.