ArticleHawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health2014
Does ethnicity play a role in the dosing of warfarin in Hawai'i?
Article in Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Genotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.Circulation. Genomic and precision medicine · 2020Trial
- The Molecular-Social-Genetic Determinants of Cardiovascular Health in Pacific Islanders.JACC. Asia · 2024Article
- COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Warfarin is the most common anticoagulant prescribed and its metabolism has been linked to two specific genes, CYP2C9 and VKORC1. This study analyzed 113 patients from 4 different ethnic backgrounds (Asian, Native Hawaiian, Portuguese, and Caucasian) and investigated the association between the mean daily dose of warfarin and ethnicity. Caucasian patients required the highest mean daily dose of warfarin 4.4 mg/day while Asian patients required the lowest mean daily dose of warfarin 2.5 mg/day. Portuguese patients and Native Hawaiian patients required mean of 3.8 mg/day. All three groups required a significantly lower dose than Caucasians. When adjusted for weight in kilograms, Native Hawaiian patients required a dose of 4.3 × 10(-2) mg/kg, Portuguese 4.4 × 10(-2) mg/kg and Asians 4.0 × 10(-2) mg/kg. These three populations had similar mean milligrams/kilogram dose requirements while Caucasians required a significantly higher dose of 5.3 × 10(-2) mg/kg. This data suggests that ethnicity should be taken into consideration when dosing warfarin.
Indexed as
Identifiers
24660123PMC3962032W1618208097What OpenQuestion holds
Registered trials
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