Evidence map›Paper›PMID 24660118›Full record

ReviewAmerican journal of clinical and experimental immunology2014

Dust events, pulmonary diseases and immune system.

Nafiseh Esmaeil, Marjan Gharagozloo, Abbas Rezaei, Gabriele Grunig

Abstract readReview
In one paragraph

Review in American journal of clinical and experimental immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  20. Evaluation of the Pulmonary Toxicity of Ambient Particulate Matter From Camp Victory, Iraq.Journal of toxicology and environmental health. Part A · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nafiseh EsmaeilDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran ; Departmentof Environmental Medicine, New York University School of Medicine Tuxedo, New York, USA.
Marjan GharagozlooDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran ; School of Pharmacy, University of Waterloo Ontario, Canada;
Abbas RezaeiDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
Gabriele GrunigDepartmentof Environmental Medicine, New York University School of Medicine Tuxedo, New York, USA ; Division of Pulmonary Medicine, Department of Medicine, New York University School of Medicine New York, USA.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
T helper 2 Inflammation & Severe Muscularization of Arteries in the Lungs.R01HL095764 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GRUNIG, GABRIELE · 2010 to 2014
$2.0M
Muscularization of pulmonary arteries induced by an adaptive immune responseR21HL092370 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GRUNIG, GABRIELE · 2009 to 2010
$413k
NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL095764NHLBI NIH HHS R21 HL092370
6 · The paper itself

Abstract

Incidences of sand storms have increased in recent years and there is evidence that these dusts can move across long distances. Sand dusts have different adverse effects on health, but one of the most important of them is pulmonary disease. After inhalation of dust, many dust particles are moved to the airways. Dust particles can be sensed by airways epithelial cells, activate macrophages, dendritic cells and innate immune cells and then initiate responses in various populations of specific immune cells such as T helper cells subsets (Th1, Th2, Th17), T cytotoxic cells and B cells. Initiation of inflammatory immune responses, activation of immune cells and releases of many cytokines, chemokines and other inflammatory molecules, have variable pathologic affects on lung in different respiratory diseases. Unfortunately control of desert dusts is more difficult than control of air pollution. For prevention and treatment of respiratory diseases that are caused by desert dusts, researchers need well-designed epidemiological studies, combined with analysis of the precise composition of sand dusts, and the precise mechanisms of the immune responses. Recognizing the exact cellular and molecular immune mechanisms would be very useful to find new approaches for treatment of desert dust associated pulmonary diseases.

Indexed as

cytokines and chemokinespulmonary diseaseSand dustsT helper cells

Identifiers

PMID24660118
PMCPMC3960758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.