Evidence map›Paper›PMID 24660109›Full record

ArticleAdvances in bioscience and biotechnology (Print)2012

Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids.

Houli Jiang, Fiona E Harrison, Kavita Jain, Samantha Benjamin, James M May, Joan P Graves, Darryl C Zeldin, John R Falck, Bruce D Hammock, John C McGiff

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in bioscience and biotechnology (Print), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Houli JiangDepartment of Pharmacology, New York Medical College, Valhalla, New York, USA.
Fiona E HarrisonDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Kavita JainDepartment of Pharmacology, New York Medical College, Valhalla, New York, USA.
Samantha BenjaminDepartment of Pharmacology, New York Medical College, Valhalla, New York, USA.
James M MayDepartment of Pharmacology, New York Medical College, Valhalla, New York, USA.
Joan P GravesNIH/NIEHS, Research Triangle Park, North Carolina, USA.
Darryl C ZeldinNIH/NIEHS, Research Triangle Park, North Carolina, USA.
John R FalckDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bruce D HammockEntomology and Cancer Center, University of California, Davis, California, USA.
John C McGiffDepartment of Pharmacology, New York Medical College, Valhalla, New York, USA.
New York Medical College · USNational Institute of Environmental Health Sciences · USThe University of Texas Southwestern Medical Center · USTriangle · USUniversity of California, Davis · USVanderbilt University · US

Funding

Vasoregulatory Function of CYP2E1-Derived EicosanoidsP01HL034300 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SCHWARTZMAN, MICHAL LANIADO · 1985 to 2015
$33.4M
TRANSPORT EFFECTS OF ARACHIDONATE METABOLITES IN PERFUSED TUBULEP01DK038226 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, NANCY J. · 1986 to 2015
$22.1M
Characterization And Functional Significance Of P450 Arachidonate EpoxygenasesZIAES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$18.6M
PROSTAGLANDINS, KININS, ANGIOTENSIN INTERACTIONR01HL025394 · NHLBI · NEW YORK MEDICAL COLLEGE · PI MC GIFF, JOHN C · 1985 to 2009
$4.1M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR37ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1998 to 2007
$3.0M
P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2M
Metabolomic study of ozone and nitronaphthalene toxicityR01ES013933 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 2005 to 2009
$1.5M
Vitamin C Transporters in the BrainR01NS057674 · NINDS · VANDERBILT UNIVERSITY · PI MAY, JAMES M. · 2008 to 2011
$1.2M
PROSTAGLANDINS KININS AND ANTGIOTENSIN INTERACTIONR37HL025394 · NHLBI · NEW YORK MEDICAL COLLEGE · PI MC GIFF, JOHN C · 1990 to 1999
–
Intramural NIH HHS Z01 ES025034NHLBI NIH HHS P01 HL034300NHLBI NIH HHS R01 HL025394NHLBI NIH HHS R37 HL025394NIDDK NIH HHS P01 DK038226NIEHS NIH HHS R01 ES002710NIEHS NIH HHS R01 ES013933NIEHS NIH HHS R37 ES002710NINDS NIH HHS R01 NS057674
6 · The paper itself

Abstract

The cardiovascular effects of vitamin C (VitC) could be mediated by epoxyeicosatrienoic acids (EETs). We aimed to study the mechanism of VitC-dependent microsomal formation of

Indexed as

Cytochrome P450Epoxyeicosatrienoic AcidsLipid HydroperoxidesPeroxygenaseVitamin C

Identifiers

PMID24660109
PMCPMC3958942
OpenAlexW2098034150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.