Evidence map›Paper›PMID 24660051›Full record

ArticleACS medicinal chemistry letters2014

An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.

Qing Jing, Huiying Li, Linda J Roman, Pavel Martásek, Thomas L Poulos, Richard B Silverman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Nitric oxide synthase and structure-based inhibitor design.Nitric oxide : biology and chemistry · 2017
    Review
  3. Article
  4. Review
  5. Structures of human constitutive nitric oxide synthases.Acta crystallographica. Section D, Biological crystallography · 2014
    Article
  6. Article
  7. Article
  8. Modern research in inflammation · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Qing JingDepartment of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, USA.
Huiying LiDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, California 92697-3900, USA.
Linda J RomanDepartment of Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78384-7760, USA.
Pavel MartásekDepartment of Biochemistry, The University of Texas Health Science Center, San Antonio, TX 78384-7760, USA ; Department of Pediatrics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Thomas L PoulosDepartments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, California 92697-3900, USA.
Richard B SilvermanDepartment of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, USA.
Northwestern University · USUniversity of California, Irvine · USThe University of Texas Health Science Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

STRUCTURAL STUDIES ON NITRIC OXIDE SYNTHASER01GM057353 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI POULOS, THOMAS L · 1998 to 2018
$6.8M
Selective inhibition of nitric oxide synthase for multiple indicationsR01GM049725 · NIGMS · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 1994 to 2018
$6.0M
Structure/Function Modularity in Nitric Oxide SynthaseR01GM052419 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MASTERS, BETTIE SUE SILER, ROMAN, LINDA J · 1996 to 2012
$3.5M
NIGMS NIH HHS R01 GM049725NIGMS NIH HHS R01 GM052419NIGMS NIH HHS R01 GM057353
6 · The paper itself

Abstract

The three important mammalian isozymes of nitric oxide synthase (NOS) are neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). Inhibitors of nNOS show promise as treatments for neurodegenerative diseases. Eight easily-synthesized compounds containing either one (

Indexed as

enzyme inhibitionneurodegenerative diseasesnitric oxidenitric oxide synthase

Identifiers

PMID24660051
PMCPMC3960082
OpenAlexW2067870537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.