ArticleDose-response : a publication of International Hormesis Society2014
Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance.
Article in Dose-response : a publication of International Hormesis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High-Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2.Oxidative medicine and cellular longevity · 2025Article
- Resveratrol and Exercise Produce Recovered Ankle and Metatarsus Joint Movements after Penetrating Lesion in Hippocampus in Male Rats.Brain sciences · 2024Article
- The effects of combined resveratrol and high intensity interval training on the hippocampus in aged male rats: An investigation into some signaling pathways related to mitochondria.Iranian journal of basic medical sciences · 2022Article
- The systemic role of SIRT1 in exercise mediated adaptation.Redox biology · 2020Review
- Effects of Dietary Supplements on Adaptations to Endurance Training.Sports medicine (Auckland, N.Z.) · 2020Review
- Beneficial effects of running and milk protein supplements on Sirtuins and risk factors of metabolic disorders in rats with low aerobic capacity.Metabolism open · 2019Article
- SIRT4 and Its Roles in Energy and Redox Metabolism in Health, Disease and During Exercise.Frontiers in physiology · 2019Review
- Capsaicinoids improve consequences of physical activity.Toxicology reports · 2018Article
- Cardiovascular Adaptive Homeostasis in Exercise.Frontiers in physiology · 2018Article
- No Additive Effects of Polyphenol Supplementation and Exercise Training on White Adiposity Determinants of High-Fat Diet-Induced Obese Insulin-Resistant Rats.Oxidative medicine and cellular longevity · 2018Article
- Nutritional implications for ultra-endurance walking and running events.Extreme physiology & medicine · 2016Review
- Activation of AMPK and its Impact on Exercise Capacity.Sports medicine (Auckland, N.Z.) · 2015Review
- Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.Medicine and science in sports and exercise · 2015Review
- Impact of Dietary Antioxidants on Sport Performance: A Review.Sports medicine (Auckland, N.Z.) · 2015Review
- Natural Compounds Modulating Mitochondrial Functions.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart, skeletal muscle and the vasculature.Molecules (Basel, Switzerland) · 2014Review
- Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.Pharmaceuticals (Basel, Switzerland) · 2014Review
- Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Low capacity runner (LCR) rats have been developed by divergent artificial selection for treadmill endurance capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running. In this study it was examined whether 12 weeks of treadmill exercise training and/or resveratrol can retrieve the low running performance of the LCR and impact mitochondrial biogenesis and quality control. Resveratrol regressed running performance in trained LCR (p<0.05). Surprisingly, exercise and resveratrol treatments significantly decreased pAMPK/AMPK, SIRT1, SIRT4, forkhead transcription factor 1 (FOXO1) and mitochondrial transcription factor A (TFAM) levels in these animals (p<0.05). Mitochondrial fusion protein, HSP78 and polynucleotide phosphorylase were significantly induced in LCR-trained, LCR-resveratrol treated, LCR-trained and resveratol treated groups compared to LCR-controls. The data indicate that the AMPK-SIRT1-NAMPT-FOXO1 axis could be important to the limited aerobic endurance capacity of low running capacity rats. Resveratrol supplementation was not beneficial in terms of aerobic endurance performance, mitochondrial biogenesis, or quality control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.