ReviewThe Clinical biochemist. Reviews2014
Physiology and its importance for reference intervals.
Review in The Clinical biochemist. Reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Trimester-specific reference interval for glycated hemoglobin in non-diabetic pregnant women: A cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Diagnostic accuracy of glycated hemoglobin and glycated albumin for detecting dysglycemia among community-dwelling older adults in China: a cross-sectional diagnostic study.BMC geriatrics · 2026Article
- Establishing Age- and Sex-Specific Reference Intervals for Thyroid Function Tests in the Older People of Eastern Anatolia: A Population-Based Indirect Approach.Medicina (Kaunas, Lithuania) · 2026Article
- Reference intervals for urine creatinine-to-specific gravity ratio as an indicator of relative creatinine excretion rate: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Evolution of reference intervals for renal-hepatic biomarkers and micronutrients in normal pregnancy during Covid-19 pandemic (2021-2022) in some hospitals of Kinshasa, Democratic Republic of the Congo.Practical laboratory medicine · 2025Article
- Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population.iScience · 2024Article
- Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements.Molecular therapy. Methods & clinical development · 2024Review
- Clinical evaluation of the reference intervals for diabetes in Chinese geriatric population: a cross-sectional cohort study protocol.BMJ open · 2024Article
- The Role and Limitations of the Reference Interval Within Clinical Chemistry and Its Reliability for Disease Detection.British journal of biomedical science · 2024Review
- Establishment of Reference Intervals of Blood Parameters Among the Healthy Afghan Population.Journal of blood medicine · 2024Article
- Functional Reference Limits: Describing Physiological Relationships and Determination of Physiological Limits for Enhanced Interpretation of Laboratory Results.Annals of laboratory medicine · 2023Review
- Establishment of Reference Intervals for Renal Function Clinical Chemistry Parameters in an Indonesian Tertiary Hospital.Archives of Razi Institute · 2023Article
- Blood count reference intervals for the Brazilian adult population: National Health Survey.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
- A Survey on Wireless Wearable Body Area Networks: A Perspective of Technology and Economy.Sensors (Basel, Switzerland) · 2022Review
- Bioreactance-derived haemodynamic parameters in the transitional phase in preterm neonates: a longitudinal study.Journal of clinical monitoring and computing · 2022Observational
- Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer.Journal of medical biochemistry · 2022Article
- Age, breed, sex and diet influence serum metabolite profiles of 2000 pet dogs.Royal Society open science · 2022Article
- Thyroid Stimulating Hormone, T3 and T4 Population-based Reference Range and Children Prevalence of Thyroid Dysfunction: First Report from South of Iran.Iranian journal of pathology · 2022Article
- Biochemical and Hematologic Reference Intervals for Anesthetized, Female, Juvenile Yorkshire Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Routine clinical chemistry and haematological test reference intervals for healthy adults in the Bhutanese population.PloS one · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reference intervals are ideally defined on apparently healthy individuals and should be distinguished from clinical decision limits that are derived from known diseased patients. Knowledge of physiological changes is a prerequisite for understanding and developing reference intervals. Reference intervals may differ for various subpopulations because of differences in their physiology, most obviously between men and women, but also in childhood, pregnancy and the elderly. Changes in laboratory measurements may be due to various physiological factors starting at birth including weaning, the active toddler, immunological learning, puberty, pregnancy, menopause and ageing. The need to partition reference intervals is required when there are significant physiological changes that need to be recognised. It is important that laboratorians are aware of these changes otherwise reference intervals that attempt to cover a widened inter-individual variability may lose their usefulness. It is virtually impossible for any laboratory to directly develop reference intervals for each of the physiological changes that are currently known, however indirect techniques can be used to develop or validate reference intervals in some difficult situations such as those for children. Physiology describes our life's journey, and it is only when we are familiar with that journey that we can appreciate a pathological departure.
Identifiers
24659833PMC3961997What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.