ArticleAge (Dordrecht, Netherlands)2014
Select aging biomarkers based on telomere length and chronological age to build a biological age equation.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association of female and male infertility with telomere length (Review).International journal of molecular medicine · 2019Pooled it
- Protein profiling reveals consequences of lifestyle choices on predicted biological aging.Scientific reports · 2015Trial
- Telomere length and appendicular lean mass over six years in older adults with overweight or obesity and metabolic syndrome: a prospective cohort study.GeroScience · 2026Article
- Different Models of Everyday Physical Activity and Occurrence of Falls Among Community-Dwelling Older Adults and Middle-Aged Citizens.Journal of clinical medicine · 2026Article
- Review
- Cultural Engagement Is Related to Decelerated Physiological Age: Doubly Robust Estimations in a National Cohort Study.Annals of the New York Academy of Sciences · 2026Article
- OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.Nature aging · 2026Article
- Social connections are differentially related to subjective age and physiological age acceleration amongst older adults.Nature communications · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Article
- Progress in the study of aging marker criteria in human populations.Frontiers in public health · 2024Review
- OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.bioRxiv : the preprint server for biology · 2023Article
- HIV-Infected Patients as a Model of Aging.Microbiology spectrum · 2023Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- An Updated Overview on the Role of Small Molecules and Natural Compounds in the "Young Science" of Rejuvenation.Antioxidants (Basel, Switzerland) · 2023Review
- Progress in biological age research.Frontiers in public health · 2023Review
- A Unified Model of Age-Related Cardiovascular Disease.Biology · 2022Review
- A machine learning-based data mining in medical examination data: a biological features-based biological age prediction model.BMC bioinformatics · 2022Article
- Design, methods and baseline characteristics of the Beijing Hospital Atherosclerosis Study: a prospective dynamic cohort study.Annals of translational medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.