Trial reportHuman brain mapping2014
Oxytocin facilitates the sensation of social stress.
Trial report in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- A systematic review and meta-analysis of experimental methods for modulating intrusive memories following lab-analogue trauma exposure in non-clinical populations.Nature human behaviour · 2024Pooled it
- Effects of mind-body therapies on depression among adolescents: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration.Human brain mapping · 2023Trial
- Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- The effect of oxytocin, gender, and ovarian hormones on stress reactivity in individuals with cocaine use disorder.Psychopharmacology · 2020Trial
- Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Oxytocin enhances the pain-relieving effects of social support in romantic couples.Human brain mapping · 2019Trial
- Oxytocin differentially modulates pavlovian cue and context fear acquisition.Social cognitive and affective neuroscience · 2017Trial
- Oxytocin biases men but not women to restore social connections with individuals who socially exclude them.Scientific reports · 2017Trial
- Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.Psychoneuroendocrinology · 2016Trial
- Oxytocin Facilitates Pavlovian Fear Learning in Males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- The influence of oxytocin on volitional and emotional ambivalence.Social cognitive and affective neuroscience · 2015Trial
- Craving Moderates the Effects of Intranasal Oxytocin on Anger in Response to Social Stress Among Veterans With Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder.Journal of clinical psychopharmacologyTrial
- Hypothalamic oxytocin neurons produce pro-anxiety effects through glutamatergic projections to the lateral hypothalamus.Cell discovery · 2026Article
- Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Effects of chronic empathic stress on synaptic efficacy, as well as short-term and long-term plasticity at the Schaffer collateral/commissural- CA1 synapses in the dorsal hippocampus of rats.Metabolic brain disease · 2024Article
- Effects of intranasal oxytocin on cigarette withdrawal and smoking in the laboratory: Differences by sex and social functioning traits.Experimental and clinical psychopharmacology · 2024Article
- Leveraging the unique social organization of California mice to study circuit-specific effects of oxytocin on behavior.Hormones and behavior · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essentially all social species experience social stress which can be a catalyst for detriments in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce anxiolytic and antistress effects, thereby qualifying the OXT system as a promising drug target in the treatment of stress-related disorders. However, recently it has been shown that OXT can have anxiogenic effects as well. In the present study, we used functional magnetic resonance imaging to scan the brains of 60 healthy men while they were exposed to social stress after they received either intranasal OXT (24 IU) or placebo treatment. Although OXT administration did not alter salivary cortisol levels as a surrogate marker of stress axis activity, our participants initially reported an increment in perceived social stress. This behavioral effect was paralleled on the neural level by increased activity in the precuneus and cingulate cortex. Taken together, our results support the hypothesis that OXT can induce a self-referential processing bias which facilitates the sensation of social stress in the absence of altered endocrine responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.