ArticleEuropean journal of pediatrics2014
Voiding urosonography with second-generation ultrasound contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux.
Article in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Determining the optimal contrast-enhanced voiding urosonography technique for vesicoureteral reflux in children and adolescents: a systematic review and network meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Diagnostic accuracy of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) study for assessment of vesicoureteral reflux in children: a meta-analysis.World journal of urology · 2019Pooled it
- Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial.Pediatric radiology · 2018Trial
- Diagnostic performance of contrast-enhanced voiding ultrasonography and direct radionuclide cystography with physiologic bladder filling volumes in pediatric vesicoureteral reflux-a prospective study.European journal of pediatrics · 2026Article
- A Comparison of Contrast-Enhanced Voiding Urosonography (CE-VUS) and Contrast Retrograde Cystourethrography (RCUG) for the Detection of Vesicoureteral Reflux in Young Dogs.Animals : an open access journal from MDPI · 2025Article
- Ultrasound contrast agent assisted ultrasonography guidance percutaneous nephrostomy for non-hydronephrotic kidney.The ultrasound journal · 2024Article
- Application of contrast-enhanced ultrasound in the surgical treatment of vesicoureteral reflux in children.Pediatric surgery international · 2023Review
- A narrative review on the applications of intracavitary contrast-enhanced ultrasonography in pediatric lower genitourinary anomalies.Frontiers in pediatrics · 2023Review
- Application of urodynamics combined with contrast-enhanced ultrasound in evaluation of the urinary tract in patients with low bladder compliance and vesicoureteric reflux who underwent bladder augmentation alone.The Kaohsiung journal of medical sciences · 2022Article
- Clinical guidelines of UTIs in children: quality appraisal with AGREE II and recommendations analysis.BMJ open · 2022Article
- Contemporary Management of Urinary Tract Infections in Children.Current treatment options in pediatrics · 2022Review
- Contrast-enhanced voiding urosonography part 2: urethral imaging.Pediatric radiology · 2021Review
- Translational research in pediatric contrast-enhanced ultrasound.Pediatric radiology · 2021Review
- Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States.Pediatric radiology · 2021Review
- Contrast-enhanced ultrasound: a comprehensive review of safety in children.Pediatric radiology · 2021Review
- Pediatric contrast-enhanced ultrasound: optimization of techniques and dosing.Pediatric radiology · 2021Review
- Contrast-enhanced voiding urosonography, part 1: vesicoureteral reflux evaluation.Pediatric radiology · 2021Review
- Contrast-enhanced voiding urosonography for the diagnosis of vesicoureteral reflux and intrarenal reflux: a comparison of diagnostic performance with fluoroscopic voiding cystourethrography.Ultrasonography (Seoul, Korea) · 2021Article
- Evaluation of the Diagnostic Value of Contrast-Enhanced Voiding Urosonography with Regard to the Further Therapy Regime and Patient Outcome-A Single-Center Experience in an Interdisciplinary Uroradiological Setting.Medicina (Kaunas, Lithuania) · 2021Article
- Contrast-enhanced voiding urosonography with intravesical administration of ultrasound contrast agent for the diagnosis of pediatric vesicoureteral reflux.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vesicoureteric reflux has been associated with paediatric urinary tract infection. Fluoroscopic micturating cystourethrography (MCU) has been the gold standard of diagnostic test for decades; however, it has been criticized owing to its lower detection rate and radiation dose to children. Therefore, new radiation-free reflux imaging modalities have been developed, in which ultrasound-based contrast-enhanced voiding urosonography (ceVUS) is a good example. However, ultrasonography has been considered as an operator-dependent examination. Therefore, our study aimed to examine the inter-observer agreement of this sonographic technique, which has not been evaluated before. Moreover, the second-generation ultrasound contrast SonoVue has been recently marketed, and the data on its efficacy on intravesical use in ceVUS is relatively scarce. Thus, we also aimed to investigate the diagnostic performance and safety profile of SonoVue-enhanced VUS in the diagnosis of vesicoureteric reflux. Our prospective comparative study compared the diagnostic performance of ceVUS with MCU in young children presenting with first episode of urinary tract infection. We performed sequential ceVUS and MCU examinations in 31 patients (62 pelvi-ureter units). Perfect inter-observer agreement (Cohen’s kappa statistics = 1.0, p < 0.001) was achieved in ceVUS, suggesting its good reliability in reflux detection and grading. Using MCU as reference, ceVUS had 100 % sensitivity and 84 % specificity and carried higher reflux detection rate than MCU (p < 0.001). There was no complication encountered. Conclusion: Voiding urosonography is a reliable, sensitive, safe and radiation-free modality in the investigation of vesicoureteric reflux in children. It should be incorporated in the diagnostic algorithm in paediatric urinary tract infection.
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Registered trials
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