ReviewIntensive care medicine2014
The intensive care management of acute ischemic stroke: an overview.
Review in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 101 citations in OpenAlex.
- Twenty-eight-day in-hospital mortality prediction for elderly patients with ischemic stroke in the intensive care unit: Interpretable machine learning models.Frontiers in public health · 2022Trial
- Combination therapy with beraprost sodium and aspirin for acute ischemic stroke: a single-center retrospective study.The Journal of international medical research · 2019Trial
- Comparison of Diagnostic Criteria for Severe Ischemic Stroke: A Retrospective Cohort Study.Brain and behavior · 2026Article
- Association of fluid balance with 3-month outcomes in severe acute ischaemic stroke.Stroke and vascular neurology · 2026Article
- Nanotechnology for ischemic stroke treatment: addressing challenges across stroke management stages.Frontiers in molecular biosciences · 2026Review
- Application of injectable hydrogels in the central and peripheral nervous system as a unique and flexible platform for neural tissue repair.Materials today. Bio · 2025Review
- Epidemiological Study of Stroke Presenting to the Emergency Department of a Tertiary Hospital: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Comparison of Esmolol and Nicardipine treatment in hypertensive acute ıschemic stroke patients.Scientific reports · 2025Article
- Fluid excess on intensive care unit after mechanical thrombectomy after acute ischemic stroke is associated with unfavorable neurological and functional outcomes: An observational cohort study.European stroke journal · 2025Observational
- Informing future randomized controlled trials of amantadine hydrochloride in neurocritical care and post-neurocritical care stroke patients through a retrospective study.BMC neurology · 2024Article
- Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction.Frontiers in neurology · 2024Article
- Effect of admission in the stroke care unit versus intensive care unit on in-hospital mortality in patients with acute ischemic stroke.BMC neurology · 2023Article
- Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke.Critical care (London, England) · 2023Article
- A Review on Therapeutic Potential of Natural Phytocompounds for Stroke.Biomedicines · 2022Review
- Outcomes of patients admitted to the ICU for acute stroke: a retrospective cohort.BMC anesthesiology · 2022Article
- Acute ischemic stroke in a university hospital intensive care unit: 1-year costs and outcome.Acta anaesthesiologica Scandinavica · 2022Article
- Outcomes of Acute Stroke Patients Requiring Mechanical Ventilation: Study Protocol for the SPICE Multicenter Prospective Observational Study.Neurocritical care · 2020Article
- Practical approach to respiratory emergencies in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Outcome Predictors of Stroke Mortality in the Neurocritical Care Unit.Frontiers in neurology · 2020Article
- Triglyceride-Glucose Index Linked to Hospital Mortality in Critically Ill Stroke: An Observational Multicentre Study on eICU Database.Frontiers in medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeAcute ischemic stroke (AIS) is a leading cause of morbidity and mortality worldwide. In part due to the availability of more aggressive treatments, increasing numbers of patients with AIS are being admitted to the intensive care unit (ICU). Despite the availability of consensus guidance for the general management of AIS, there is little evidence to support its ICU management. The purpose of this article is to provide a contemporary perspective, and our recommendations, on the ICU management of AIS.
methodsWe reviewed the current general AIS guidelines provided by the European Stroke Organisation, the American Stroke Association, and the U.K. National Institute for Health and Care Excellence, as well as the wider literature, for the data most relevant to the ICU management of AIS.
resultsThere are four interventions in AIS supported by class I evidence: care on a stroke unit, intravenous tissue plasminogen activator within 4.5 h of stroke onset, aspirin within 48 h of stroke onset, and decompressive craniectomy for supratentorial malignant hemispheric cerebral infarction. However, robust evidence for specific AIS management principles in the ICU setting is weak. Management principles currently focus on airway and ventilation management, hemodynamic and fluid optimization, fever and glycemic control, management of anticoagulation, antiplatelet and thromboprophylaxis therapy, control of seizures and surgical interventions for malignant middle cerebral artery and cerebellar infarctions.
conclusionsWe have provided our recommendations for the principles of ICU management of AIS, based on the best available current evidence. Encouragement of large-scale recruitment of patients with AIS into clinical trials should aid the development of robust evidence for the benefit of different interventions in the ICU on outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.