ArticleAge (Dordrecht, Netherlands)2014
The influence on sarcopenia of muscle quality and quantity derived from magnetic resonance imaging and neuromuscular properties.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- Exercise effects on muscle quality in older adults: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia.GeroScience · 2021Trial
- Skeletal muscle as a dynamic immunological niche for vaccination.Frontiers in immunology · 2026Review
- Article
- Effects of fatigue on motor unit characteristics in isometric elbow contractions across age groups.Frontiers in neuroscience · 2025Article
- Imaging of Sarcopenia in Type 2 Diabetes Mellitus.Clinical interventions in aging · 2024Review
- Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice.Journal of cachexia, sarcopenia and muscle · 2023Article
- Human skeletal muscle-specific atrophy with aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Current Approach to the Diagnosis of Sarcopenia in Heart Failure: A Narrative Review on the Role of Clinical and Imaging Assessments.Circulation. Heart failure · 2022Review
- The non-modifiable factors age, gender, and genetics influence resistance exercise.Frontiers in aging · 2022Review
- Combination of DXA and BIS Predicts Jump Power Better Than Traditional Measures of Sarcopenia.JBMR plus · 2021Article
- The role of novel motor unit magnetic resonance imaging to investigate motor unit activity in ageing skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2021Review
- The Role of Imaging Biomarkers in the Assessment of Sarcopenia.Diagnostics (Basel, Switzerland) · 2020Article
- Imaging of sarcopenia: old evidence and new insights.European radiology · 2020Review
- Dynamic Force Production Capacities Between Coronary Artery Disease Patients vs. Healthy Participants on a Cycle Ergometer.Frontiers in physiology · 2019Article
- Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age.Frontiers in physiology · 2019Article
- Skeletal muscle performance and ageing.Journal of cachexia, sarcopenia and muscle · 2018Review
- Perceived Versus Performance Fatigability in Patients With Rheumatoid Arthritis.Frontiers in physiology · 2018Review
- Maintaining Motor Units into Old Age: Running the Final Common Pathway.European journal of translational myology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relative contributions of intrinsic and extrinsic neuromuscular factors on sarcopenia are poorly understood. The associations among age-related declines of strength, muscle mass, and muscle quality in response to motor unit (MU) loss have not been systematically investigated in the same groups of subjects. The purpose was to assess MU loss, MRI-derived muscle cross-sectional area (CSA), muscle protein quantity (MPQ), and normalized strength of the dorsiflexors in one group of young (~25 years) adult males compared with two groups of healthy men aged 60–85 years. Muscle strength was assessed on a dynamometer and was ~25 % lower in both older groups, but CSA was less only in the older (>75 years) men, with no differences between the young and old (60–73 years). Normalized strength tended to be lower in both groups of aged men compared to young. For MPQ, only the older men showed ~8 % lower values than the young and old men. Older men had fewer functioning MUs than old, and both groups of aged men had fewer MUs than young men. Muscle quality appears to be maintained in the old likely due to compensatory MU remodeling, but in the older group (>75 years), MU loss was higher and MPQ was lower.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.