SynthesisPloS one2014
Diagnostic yield of the light blue crest sign in gastric intestinal metaplasia: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.Gastroenterology · 2021Guideline
- Guideline
- EGID: A Comprehensive Multi-label Endoscopic Image Dataset for Gastritis Classification.Scientific data · 2026Article
- Endoscopic Diagnosis of Chronic Atrophic Gastritis and Early Gastric Cancer: From Basics to Advanced Imaging.Cancers · 2026Review
- Early Detection of Gastric Cancer: Linking Epidemiology, Pathophysiology, and Innovations in Digestive Endoscopy.Diseases (Basel, Switzerland) · 2026Review
- Recent advancement in endoscopic diagnosis for risk stratification of gastric cancer.Clinical endoscopy · 2025Review
- Update understanding on diagnosis and histopathological examination of atrophic gastritis: A review.World journal of gastrointestinal oncology · 2024Review
- Latest Advances in Endoscopic Detection of Oesophageal and Gastric Neoplasia.Diagnostics (Basel, Switzerland) · 2024Review
- Usefulness of optical enhancement endoscopy combined with magnification to improve detection of intestinal metaplasia in the stomach.Endoscopy international open · 2022Article
- Advances in the Aetiology & Endoscopic Detection and Management of Early Gastric Cancer.Cancers · 2021Review
- Ultra-magnifying narrow-band imaging for endoscopic diagnosis of gastric intestinal metaplasia: a pilot image analysis study.Endoscopy international open · 2021Article
- Diagnostic value of linked color imaging based on endoscopy for gastric intestinal metaplasia: a systematic review and meta-analysis.Annals of translational medicine · 2021Article
- Recent advances in the detection and management of early gastric cancer and its precursors.Frontline gastroenterology · 2021Review
- Feedback from artificial intelligence improved the learning of junior endoscopists on histology prediction of gastric lesions.Endoscopy international open · 2020Article
- Diagnosis of early gastric cancer using image enhanced endoscopy: a systematic approach.Translational gastroenterology and hepatology · 2020Review
- Identifying high-risk individuals for gastric cancer surveillance from western and eastern perspectives: Lessons to learn and possibility to develop an integrated approach for daily practice.World journal of gastroenterology · 2019Review
- Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy.GE Portuguese journal of gastroenterology · 2018Review
- The evolving role of endoscopy in the diagnosis of premalignant gastric lesions.F1000Research · 2018Review
- Evidence based review of the impact of image enhanced endoscopy in the diagnosis of gastric disorders.World journal of gastrointestinal endoscopy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnostic yield of light blue crest(LBC) sign, which was observed by narrow band imaging with magnification endoscopy(NBI-ME), in detecting gastric intestinal metaplasia(IM) has shown variable results.
objectiveWe aimed to assess the diagnostic value of LBC under NBI-ME for detecting gastric IM.
methodsWe performed a literature search of the Medline/PubMed, Embase, Web of Science, Science Direct and the Cochrane Library Databases; and a meta-analysis of pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and SROC area under the curve, using fixed- and random-effects models, for the accuracy of LBC-based IM diagnosis.
resultsWe initially included 4 articles, but excluded 1 article to counter significant heterogeneity. When pooled, the remaining 3 articles, which included 247 patients with 721 lesions, showed the following patterns in IM diagnosis: sensitivity: 0.90 (95% confidence interval [CI] 0.86-0.92); specificity: 0.90 (95% CI 0.86-0.93), positive likelihood ratio: 8.98 (95% CI 6.42-12.58), negative likelihood ratio: 0.12 (95% CI 0.09-0.16), and SROC area under the curve: 0.9560. LIMITATIONS: As the studies varied by their definitions for positive LBC, endoscopy types, biopsy protocols, race of patient cohort, and physicians' proficiency, some sample sizes were limited so that subgroup analyses could not be performed.
conclusionWe concluded that observing LBC under NBI-ME is an accurate and precise means of diagnosing gastric IM.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.