ArticlePloS one2014
Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Neonatal sepsis definitions from randomised clinical trials.Pediatric research · 2023Pooled it
- Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis.BMC pediatrics · 2020Pooled it
- Methodological framework for the surveillance of healthcare-associated infections in high-risk infants: the NeoIPC surveillance core module protocol.Antimicrobial resistance and infection control · 2026Article
- Comparison of Neonatal Morbidity and Mortality Following Spontaneous and Medically Indicated Preterm Births: A Retrospective Population-Based Study Using Data from the Slovenian National Perinatal Information System 2013-2018.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Association of anemia and platelet activation with necrotizing enterocolitis with or without sepsis among low birth weight neonates: a case-control study.Frontiers in pediatrics · 2023Article
- Determinants of Mortality in a Neonatal Intensive Care Unit in Athens, Greece: A Case-Control Study.Cureus · 2022Article
- Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective.Frontiers in pediatrics · 2022Review
- Time to occurrence of necrotizing enterocolitis and its predictors among low birth weight neonates admitted at neonatal intensive care unit of felege hiwot compressive specialized hospital BahirDar, Ethiopia, 2021: A retrospective follow-up study.Frontiers in pediatrics · 2022Article
- The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia: A Cross-sectional Study.Global pediatric health · 2021Article
- Prenatal stress increases IgA coating of offspring microbiota and exacerbates necrotizing enterocolitis-like injury in a sex-dependent manner.Brain, behavior, and immunity · 2020Article
- Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis.Pediatric surgery international · 2020Article
- Recent advances in understanding necrotizing enterocolitis.F1000Research · 2019Review
- Antibiotic exposure and development of necrotizing enterocolitis in very preterm neonates.Paediatrics & child health · 2018Article
- Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland.Annals of clinical microbiology and antimicrobials · 2017Article
- Optimizing the Use of Antibacterial Agents in the Neonatal Period.Paediatric drugs · 2016Article
- Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.Breastfeeding medicine : the official journal of the Academy of Breastfeeding MedicineArticle
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns.
methodsProspective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD).
resultsNEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed.
conclusionsA high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens.
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