ArticleInternational journal of molecular sciences2014
Investigation into variation of endogenous metabolites in bone marrow cells and plasma in C3H/He mice exposed to benzene.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Chemical composition and bioinsecticidal activity of bioinputs produced by Saccharopolyspora spinosa.Applied microbiology and biotechnology · 2025Article
- Hematological Parameters of Gasoline Station Workers at Hosanna Town, Southwest Ethiopia: A Comparative Cross-Sectional Study.Journal of blood medicine · 2024Article
- Article
- Plasma metabolomics study reveals the critical metabolic signatures for benzene-induced hematotoxicity.JCI insight · 2022Article
- Metabolome-wide association study of occupational exposure to benzene.Carcinogenesis · 2021Article
- Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia.Journal of blood medicine · 2021Article
- Global Identification of HIF-1α Target Genes in Benzene Poisoning Mouse Bone Marrow Cells.International journal of environmental research and public health · 2018Article
- Plasma metabonomics investigation reveals involvement of fatty acid oxidation in hematotoxicity in Chinese benzene-exposed workers with low white blood cell count.Environmental science and pollution research international · 2018Article
- Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice.International journal of environmental research and public health · 2016Article
- Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure.International journal of environmental research and public health · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzene is identified as a carcinogen. Continued exposure of benzene may eventually lead to damage to the bone marrow, accompanied by pancytopenia, aplastic anemia or leukemia. This paper explores the variations of endogenous metabolites to provide possible clues for the molecular mechanism of benzene-induced hematotoxicity. Liquid chromatography coupled with time of flight-mass spectrometry (LC-TOF-MS) and principal component analysis (PCA) was applied to investigate the variation of endogenous metabolites in bone marrow cells and plasma of male C3H/He mice. The mice were injected subcutaneously with benzene (0, 300, 600 mg/day) once daily for seven days. The body weights, relative organ weights, blood parameters and bone marrow smears were also analyzed. The results indicated that benzene caused disturbances in the metabolism of oxidation of fatty acids and essential amino acids (lysine, phenylalanine and tyrosine) in bone marrow cells. Moreover, fatty acid oxidation was also disturbed in plasma and thus might be a common disturbed metabolic pathway induced by benzene in multiple organs. This study aims to investigate the underlying molecular mechanisms involved in benzene hematotoxicity, especially in bone marrow cells.
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