ArticleCell death and differentiation2014
The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1.
Article in Cell death and differentiation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review.Cancer cell international · 2023Review
- Bioinformatics analysis of aberrantly expressed exosomal lncRNAs in oral squamous cell carcinoma (CAL-27 vs. oral epithelial) cells.Oncology letters · 2020Article
- A two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer.Scientific reports · 2018Article
- The novel hsa-miR-12528 regulates tumourigenesis and metastasis through hypo-phosphorylation of AKT cascade by targeting IGF-1R in human lung cancer.Cell death & disease · 2018Article
- HSP90: A Novel Target Gene of miRNA-628-3p in A549 Cells.BioMed research international · 2018Article
- The Novel miR-9600 Suppresses Tumor Progression and Promotes Paclitaxel Sensitivity in Non-small-cell Lung Cancer Through Altering STAT3 Expression.Molecular therapy. Nucleic acids · 2016Article
- The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2016Article
- Hsa-miR-623 suppresses tumor progression in human lung adenocarcinoma.Cell death & disease · 2016Article
- Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- C-reactive protein levels in the perioperative period as a predictive marker of endoscopic recurrence after ileo-colonic resection for Crohn's disease.Cell death discovery · 2016Article
- [Advanced Research on MicroRNAs and EGFR-TKIs Secondary Resistance].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Review
- Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2.Scientific reports · 2015Article
- MicroRNAs in apoptosis, autophagy and necroptosis.Oncotarget · 2015Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs have crucial roles in lung cancer cell development. They regulate cell growth, proliferation and migration by mediating the expression of tumor suppressor genes and oncogenes. We identified and characterized the novel miR-9500 in human lung cancer cells. The miR-9500 forms a stem-loop structure and is conserved in other mammals. The expression levels of miR-9500 were reduced in lung cancer cells and lung cancer tissues compared with normal tissues, as verified by TaqMan miRNA assays. It was confirmed that the putative target gene, Akt1, was directly suppressed by miR-9500, as demonstrated by a luciferase reporter assay. The miR-9500 significantly repressed the protein expression levels of Akt1, as demonstrated via western blot, but did not affect the corresponding mRNA levels. Akt1 has an important role in lung carcinogenesis, and depletion of Akt1 has been shown to have antiproliferative and anti-migratory effects in previous studies. In the current study, the overexpression of miR-9500 inhibited cell proliferation and the expression of cell cycle-related proteins. Likewise, the overexpression of miR-9500 impeded cell migration in human lung cancer cells. In an in vivo assay, miR-9500 significantly suppressed Fluc expression compared with NC and ASO-miR-9500, suggesting that cell proliferation was inhibited in nude mice. Likewise, miR-9500 repressed tumorigenesis and metastasis by targeting Akt1. These data indicate that miR-9500 might be applicable for lung cancer therapy.
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