ArticleMedicine and science in sports and exercise2014
Exercise training augments regional bone and marrow blood flow during exercise.
Article in Medicine and science in sports and exercise, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04083794 (Exploration of Blood Flow Regulation to Bone in Humans), which is not on this map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploration of Blood Flow Regulation to Bone in Humans
Who cites it
21 citing papers in PubMed.
- Sitting foot: posture dependent changes of volume, edema and perfusion of the foot. A prospective interventional study with 27 volunteers.BMC musculoskeletal disorders · 2024Trial
- Transcriptomic insights into exercise-induced trabecular bone microarchitectural adaptations following combined aerobic and resistance training in mice.Scientific reports · 2026Article
- Vascular and musculoskeletal interactions: structure, function, and therapeutic strategies for sarcopenia and osteoporosis.MedScience · 2026Review
- Effects of different types of exercise over 24 weeks on bone mineral density in postmenopausal women: A systematic review with pairwise and network meta-analysis of randomized controlled trials.Journal of sport and health science · 2026Review
- Intra-apheresis Cycling to Improve the Clinical Efficacy of Peripheral Blood Stem Cell Donations.Sports medicine (Auckland, N.Z.) · 2025Review
- Aerobic exercise training-induced bone and vascular adaptations in mice lacking adiponectin.Bone · 2025Article
- Effects of long-term voluntary wheel running and selective breeding for wheel running on femoral nutrient canals.Journal of anatomy · 2024Article
- Clodronate disodium does not produce measurable effects on bone metabolism in an exercising, juvenile, large animal model.PloS one · 2024Article
- Neurovascular coupling in bone regeneration.Experimental & molecular medicine · 2022Review
- Moderate-Intensity Exercise Preserves Bone Mineral Density and Improves Femoral Trabecular Bone Microarchitecture in Middle-Aged Mice.Journal of bone metabolism · 2022Article
- The impact of aging and physical training on angiogenesis in the musculoskeletal system.PeerJ · 2022Article
- Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers: Appraising Exercise-Induced Immuno-Modulation As An Integral Mechanism.Frontiers in oncology · 2022Review
- Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?Life (Basel, Switzerland) · 2021Review
- Trabecular Bone Microarchitecture Improvement Is Associated With Skeletal Nerve Increase Following Aerobic Exercise Training in Middle-Aged Mice.Frontiers in physiology · 2021Article
- The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis.BioMed research international · 2019Review
- Near infrared spectroscopy for measuring changes in bone hemoglobin content after exercise in individuals with spinal cord injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone.The Journal of endocrinology · 2017Review
- Insulin-Stimulated Bone Blood Flow and Bone Biomechanical Properties Are Compromised in Obese, Type 2 Diabetic OLETF Rats.JBMR plus · 2017Article
- Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Influence of endurance running on calcaneal bone stiffness in male and female runners.European journal of applied physiology · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
introductionThe principal nutrient artery to the femur demonstrates an increase in nitric oxide-mediated vasodilation in rats after treadmill exercise training. The present study sought to determine whether exercise training improves hindlimb bone and marrow blood flow distribution at rest and during exercise.
methodsSix 8-month old male Sprague-Dawley rats were exercise trained (ET) with treadmill walking at 15 m · min(-1) up a 15° incline for 60 min · d(-1) over a 10- to 12-wk period. Sedentary (SED) control animals were acclimated to treadmill exercise for 5 min · d(-1) during the week preceding the blood flow measurements. Blood flow to nine distinct regions of the femur, tibia, and fibula was determined at rest and during low-intensity exercise (15 m · min(-1) walking, 0° incline) using the reference sample microsphere method.
resultsThe results demonstrate an augmentation of exercise hyperemia above that observed in SED rats during exercise in only one region of the bone, the femoral diaphysis, of ET rats. However, whereas exercise hyperemia occurred in three of the nine hindlimb bone regions measured in SED rats, exercise hyperemia occurred in seven of nine regions in ET rats.
conclusionsThese data indicate an increase in generalized hindlimb bone and marrow blood flow during physical activity after a period of exercise training. Elevations in regional bone and marrow blood flow after training may augment medullary pressure and bone interstitial fluid flow, thus benefiting bone integrity.
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