ArticlePloS one2014
Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Roles of Histone H2B, H3 and H4 Variants in Cancer Development and Prognosis.International journal of molecular sciences · 2024Review
- H3.1/3.2 regulate the initial progression of the gene expression program.Nucleic acids research · 2024Article
- The Role of the Histone Variant H2A.Z in Metazoan Development.Journal of developmental biology · 2022Review
- Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia.Leukemia · 2021Article
- Asymmetrical deposition and modification of histone H3 variants are essential for zygote development.Life science alliance · 2021Article
- Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay.eLife · 2021Article
- Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure.Scientific reports · 2018Article
- Regulation of zygotic gene activation by chromatin structure and epigenetic factors.The Journal of reproduction and development · 2017Review
- Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.Nature communications · 2017Article
- The role of enhancers in cancer.Nature reviews. Cancer · 2016Review
- Article
- Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching.Epigenetics · 2016Article
- Review
- Histone variants as emerging regulators of embryonic stem cell identity.Epigenetics · 2015Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide distribution of the majority of H2A and H3 variants (H2A, H2AX, H2AZ, macroH2A, H3.1, H3.2 and H3.3) was simultaneously investigated in mouse embryonic stem cells by chromatin immunoprecipitation sequencing. Around the transcription start site, histone variant distribution differed between genes possessing promoters of high and low CpG density, regardless of their expression levels. In the intergenic regions, regulatory elements were enriched in H2A.Z and H3.3, whereas repeat elements were abundant in H2A and macroH2A, and H3.1, respectively. Analysis of H2A and H3 variant combinations composing nucleosomes revealed that the H2A.Z and H3.3 combinations were present at a higher frequency throughout the genome than the other combinations, suggesting that H2A.Z and H3.3 associate preferentially with each other to comprise the nucleosomes independently of genome region. Finally, we found that chromatin was unstable only in regions where it was enriched in both H2A.Z and H3.3, but strongly quantified stable in regions in which only H3.3 was abundant. Therefore, histone variant composition is an important determinant of chromatin structure, which is associated with specific genomic functions.
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