ArticleOncotarget2014
p63 transcriptionally regulates the expression of matrix metallopeptidase 13.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- The Coordinated Interplay Between MMP13 and Pro-Migratory MMPs in Collective Cell Migration of Zebrafish Keratocytes.International journal of molecular sciences · 2025Article
- Multiscale model of the different modes of cancer cell invasion.Bioinformatics (Oxford, England) · 2023Article
- Article
- Commensal microbes and p53 in cancer progression.Biology direct · 2020Review
- Cancer predictive studies.Biology direct · 2020Review
- Comparative Analysis of P63, Maspin and Matrix Metalloproteinase 2 Expression in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of Salivary Glands.Journal of dentistry (Shiraz, Iran) · 2020Article
- p63 at the Crossroads between Stemness and Metastasis in Breast Cancer.International journal of molecular sciences · 2019Review
- Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.Developmental biology · 2018Article
- Sustained protein synthesis and reduced eEF2K levels in TAp73Cell cycle (Georgetown, Tex.) · 2018Article
- p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.PLoS genetics · 2017Article
- Ultraconserved long non-coding RNA uc.63 in breast cancer.Oncotarget · 2017Article
- Article
- p73 regulates basal and starvation-induced liver metabolism in vivo.Oncotarget · 2015Article
- TAp73 transcriptionally represses BNIP3 expression.Cell cycle (Georgetown, Tex.) · 2015Article
- Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.Oncotarget · 2015Article
- The microRNA feedback regulation of p63 in cancer progression.Oncotarget · 2015Review
- Pathway Regulation of p63, a Director of Epithelial Cell Fate.Frontiers in endocrinology · 2015Review
- TAp73 promotes anabolism.Oncotarget · 2014Article
- Article
- p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch.Cell cycle (Georgetown, Tex.) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Here we show that p63 transcriptionally controls the expression of the matrix metallopeptidase 13 (MMP13). p63 binds a p53-like responsive element in the human promoter of MMP13, thus promoting the activation of its transcription. The catalytic activity of MMP13 is required in high invasion capacity of metastatic cancer cells, however, although p63 and MMP13 expression correlates in cancer patients, their co-expression does not predict cancer patient survival. Our results demonstrate that p63 directly controls MMP13 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.