SynthesisPloS one2014
Recipient-related clinical risk factors for primary graft dysfunction after lung transplantation: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Inhaled nitric oxide after lung transplantation: a systematic review and meta-analysis of prospective studies.Journal of cardiothoracic surgery · 2026Pooled it
- Incidence of primary graft dysfunction and its associated risk factors after lung transplantation: a systematic review and meta-analysis.Surgery today · 2025Pooled it
- Primary Graft Dysfunction After Lung Transplantation: A Temporal Classification and Machine Learning Clustering.Transplantation direct · 2026Article
- Trends in primary graft dysfunction and early mortality following lung transplantation: A single center experience.JHLT open · 2026Article
- Association between intraoperative fluid volume and 30-day mortality in patients undergoing lung transplantation: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Machine Learning-Based Predictive Model for Grade 3 Primary Graft Dysfunction Following Lung Transplantation: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Impact of Intraoperative Albumin Use During Lung Transplantation on Primary Graft Dysfunction.Journal of clinical medicine · 2025Article
- Primary Graft Dysfunction in Lung Transplantation: An Overview of the Molecular Mechanisms.International journal of molecular sciences · 2025Review
- A nationwide survey on current practices in anesthesia management for lung transplantation in China.Scientific reports · 2025Article
- Allogeneic mesenchymal stromal cell therapy on primary graft dysfunction after lung transplantation.JHLT open · 2025Article
- Lung transplantation for interstitial lung disease.Breathe (Sheffield, England) · 2025Review
- Lung Transplant Outcomes in Patients With Preoperative Catheterization Indicating Group 2 Pulmonary Hypertension.Pulmonary circulation · 2025Article
- Transcatheter mitral valve repair with MitraClip® enabling single lung transplantation: A case report.Heliyon · 2025Article
- Long Term Outcomes of Lung Transplantation in Sensitized Patients Following Eculizumab Use With the Desensitization Protocol.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Contrasting predictors of severe primary graft dysfunction following transplant for chronic and acute respiratory failure.Journal of thoracic disease · 2024Article
- Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients.Clinics and practice · 2024Article
- Ex Vivo Lung Perfusion and Primary Graft Dysfunction Following Lung Transplantation: A Contemporary United Network for Organ Sharing Database Analysis.Journal of clinical medicine · 2024Article
- Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Beneficial effects of extracorporeal membrane oxygenation over cardiopulmonary bypass in living-donor lobar lung transplantation.JHLT open · 2024Article
- Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Herein, we carried out a systematic review and meta-analysis of published literature to identify recipient-related clinical risk factors associated with PGD development.
methodA systematic search of electronic databases (PubMed, Embase, Web of Science, Cochrane CENTRAL, and Scopus) for studies published from 1970 to 2013 was performed. Cohort, case-control, or cross-sectional studies that examined recipient-related risk factors of PGD were included. The odds ratios (ORs) or mean differences (MDs) were calculated using random-effects models.
resultThirteen studies involving 10042 recipients met final inclusion criteria. From the pooled analyses, female gender (OR 1.38, 95% CI 1.09 to 1.75), African American (OR 1.82, 95%CI 1.36 to 2.45), idiopathic pulmonary fibrosis (IPF) (OR 1.78, 95% CI 1.49 to 2.13), sarcoidosis (OR 4.25, 95% CI 1.09 to 16.52), primary pulmonary hypertension (PPH) (OR 3.73, 95%CI 2.16 to 6.46), elevated BMI (BMI≥25 kg/m2) (OR 1.83, 95% CI 1.26 to 2.64), and use of cardiopulmonary bypass (CPB) (OR 2.29, 95%CI 1.43 to 3.65) were significantly associated with increased risk of PGD. Age, cystic fibrosis, secondary pulmonary hypertension (SPH), intra-operative inhaled nitric oxide (NO), or lung transplant type (single or bilateral) were not significantly associated with PGD development (all P>0.05). Moreover, a nearly 4 fold increased risk of short-term mortality was observed in patients with PGD (OR 3.95, 95% CI 2.80 to 5.57).
conclusionsOur analysis identified several recipient related risk factors for development of PGD. The identification of higher-risk recipients and further research into the underlying mechanisms may lead to selective therapies aimed at reducing this reperfusion injury.
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