Evidence map›Paper›PMID 24658016›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2014

Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.

Edward A Pankey, Modar Kassan, Soo-Kyoung Choi, Khalid Matrougui, Bobby D Nossaman, Albert L Hyman, Philip J Kadowitz

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Analysis of cardiovascular responses to the H2S donors Na2S and NaHS in the rat.American journal of physiology. Heart and circulatory physiology · 2015
    Article
  8. Analysis of erectile responses to bradykinin in the anesthetized rat.American journal of physiology. Heart and circulatory physiology · 2015
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Edward A PankeyDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana;
Modar KassanDepartment of Physiology, Tulane University School of Medicine, New Orleans, Louisiana;
Soo-Kyoung ChoiDepartment of Physiology, Yonsei University College of Medicine, Seoul, Korea;
Khalid MatrouguiDepartment of Physiological Sciences, Eastern Virginia University Medical School, Norfolk, Virginia; and.
Bobby D NossamanDepartment of Anesthesia, Ochsner Clinic Foundation, Jefferson, Louisiana.
Albert L HymanDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana;
Philip J KadowitzDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana; pkadowi@tulane.edu.
Tulane University · USEastern Virginia Medical School · USOchsner Medical Center · USYonsei University · KR

Funding

CARDIOPULMONARY SURGERY RESEARCHR01HL062000 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KADOWITZ, PHILIP J · 2000 to 2008
$2.5M
Stem Cell Therapy for Pulmonary HypertensionR01HL077421 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KADOWITZ, PHILIP J · 2005 to 2008
$1.9M
NHLBI NIH HHS HL-62000NHLBI NIH HHS HL-77421NHLBI NIH HHS R01 HL062000NHLBI NIH HHS R01 HL077421
6 · The paper itself

Abstract

The effects of 1H-[1,2,4]-oxadizaolo[4,3-]quinoxaline-1-one (ODQ), an inhibitor of the activation of soluble guanylate cyclase (sGC) on responses to NO donors acetylcholine (ACh) and bradykinin (BK) were investigated in the pulmonary and systemic vascular beds of the rat. In these studies the administration of ODQ in a dose of 5 mg/kg iv attenuated vasodilator responses to five different NO donors without inhibiting responses to ACh and BK in the systemic and pulmonary vascular beds of the rat. Vasodilator responses to ACh were not inhibited by l-NAME or the transient receptor vanilloid type 4 (TRPV4) antagonist GSK-2193874, which attenuated vasodilator responses to the TRPV4 agonist GSK-1016790A. ODQ did not inhibit vasodilator responses to agents reported to act in an NO-independent manner or to vasoconstrictor agents, and ODQ did not increase blood methemoglobin levels, suggesting that off target effects were minimal. These results show that ODQ in a dose that inhibited NO donor-mediated responses did not alter vasodilator responses to ACh in the pulmonary and systemic vascular beds and did not alter systemic vasodilator responses to BK. The present results indicate that decreases in pulmonary and systemic arterial pressures in response to ACh are not mediated by the activation of sGC or TRPV4 channels and that ODQ can be used to study the role of the activation of sGC in mediating vasodilator responses in the rat.

Indexed as

AcetylcholineAnimalsArterial PressureBradykininEnzyme InhibitorsGuanylate CyclaseMaleNG-Nitroarginine Methyl EsterOxadiazolesQuinoxalinesRatsRats, Sprague-DawleyReceptors, Cytoplasmic and NuclearSoluble Guanylyl CyclaseTRPV Cation ChannelsVasodilation1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-oneAcetylcholineBradykininEnzyme InhibitorsGuanylate CyclaseNG-Nitroarginine Methyl EsterOxadiazolesQuinoxalinesReceptors, Cytoplasmic and NuclearSoluble Guanylyl CyclaseTrpv4 protein, ratTRPV Cation ChannelsVasodilator Agentspulmonary vascular bedtransient receptor vanilloid typevasodilation

Identifiers

PMID24658016
PMCPMC4042198
OpenAlexW2005080771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.