ArticleNature genetics2014
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.Head and neck pathology · 2022Pooled it
- A case of subperiosteal clavicular chondromyxoid fibroma in a 52-year-old man: emphasis on diagnostic utility of GRM1 immunohistochemistry.Skeletal radiology · 2026Article
- Nano-RAPID: Integrated Diagnosis for Sarcoma Using a Nanopore Sequencer.Genes, chromosomes & cancer · 2026Article
- Test Yourself Answer: A rare case of knee pain.Skeletal radiology · 2026Article
- H3F3B gene mutation in chondroblastomas: a multicenter study.Acta orthopaedica et traumatologica turcica · 2026Article
- Chondromyxoid fibroma with limited or no chondromyxoid stroma: A clinicopathological study of 3 cases.Virchows Archiv : an international journal of pathology · 2026Article
- Detection of known gene fusions in cancer cell lines using whole-genome bisulfite sequencing data.Scientific reports · 2026Article
- Sinonasal Tract Osteochondromyxoma: Future Directions Beyond Morphologic Description.Head and neck pathology · 2025Article
- Sinonasal Tract Osteochondromyxoma: An Underrecognized Tumor Easily Mistaken for Nasal Chondromesenchymal Hamartoma.Head and neck pathology · 2025Article
- Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers.Cancer medicine · 2025Review
- Chondromyxoid Fibroma of Phalanges.Sultan Qaboos University medical journal · 2025Article
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- Article
- Review
- Subcutaneous chondromyxoid fibroma with a novel PNISR::GRM1 fusion-report of a primary soft tissue tumour without connection to an underlying bone.Virchows Archiv : an international journal of pathology · 2023Article
- ACell reports. Medicine · 2023Article
- Giant cell tumor of bone: An update, including spectrum of pathological features, pathogenesis, molecular profile and the differential diagnoses.Histology and histopathology · 2023Review
- Experimentally Deduced Criteria for Detection of Clinically Relevant Fusion 3' Oncogenes from FFPE Bulk RNA Sequencing Data.Biomedicines · 2022Article
- A Comprehensive Understanding of the Genomic Bone Tumor Landscape: A Multicenter Prospective Study.Frontiers in oncology · 2022Article
- Systematic investigation of promoter substitutions resulting from somatic intrachromosomal structural alterations in diverse human cancers.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is implicated in several neurological and psychiatric disorders. It is increasingly recognized that such receptors may also have a role in tumor growth. Here we provide direct evidence of aberrant glutamate signaling in the development of a locally aggressive bone tumor, chondromyxoid fibroma (CMF). We subjected a series of CMFs to whole-genome mate-pair sequencing and RNA sequencing and found that the glutamate receptor gene GRM1 recombines with several partner genes through promoter swapping and gene fusion events. The GRM1 coding region remains intact, and 18 of 20 CMFs (90%) showed a more than 100-fold and up to 1,400-fold increase in GRM1 expression levels compared to control tissues. Our findings unequivocally demonstrate that direct targeting of GRM1 is a necessary and highly specific driver event for CMF development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.