Evidence map›Paper›PMID 24657998›Full record

ReviewCurrent opinion in cell biology2014

The multifunctional nuclear pore complex: a platform for controlling gene expression.

Christopher Ptak, John D Aitchison, Richard W Wozniak

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Structures and mRNP remodeling mechanism of the TREX-2 complex.Structure (London, England : 1993) · 2025
    Article
  5. Nucleoporin-associated steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2025
    Review
  6. Article
  7. Review
  8. Nuclear mRNA export.Acta biochimica et biophysica Sinica · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The 3D Genome: From Structure to Function.International journal of molecular sciences · 2021
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Christopher PtakDepartment of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
John D AitchisonSeattle Biomedical Research Institute and Institute for Systems Biology, 307 Westlake Ave N, Seattle, WA 98109, USA. Electronic address: john.aitchison@seattlebiomed.org.
Richard W WozniakDepartment of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address: rick.wozniak@ualberta.ca.
University of Alberta · CAInstitute for Systems Biology · US

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6M
New Tools for Exploring the Dynamic Interactome (Renewal)U54GM103511 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2012 to 2013
$6.2M
Nucleocytoplasmic transport: a target for cellular controlU01GM098256 · NIGMS · ROCKEFELLER UNIVERSITY · PI AITCHISON, JOHN D., ROUT, MICHAEL P · 2011 to 2014
$3.0M
CIHR MOP 106502CIHR MOP 130404NIGMS NIH HHS 1U01GM098256-01NIGMS NIH HHS P50 GM076547NIGMS NIH HHS U01 GM098256NIGMS NIH HHS U54 GM103511
6 · The paper itself

Abstract

In addition to their established roles in nucleocytoplasmic transport, the intimate association of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these structures influence peripheral chromatin structure and regulate gene expression. These ideas have their roots in morphological observations, however recent years have seen the identification of physical interactions between NPCs, chromatin, and the transcriptional machinery. Key insights into the molecular functions of specific NPC proteins have uncovered roles for these proteins in transcriptional activation and elongation, mRNA processing, as well as chromatin structure and localization. Here, we review recent studies that provide further molecular detail on the role of specific NPC components as distinct platforms for these chromatin dependent processes.

Indexed as

Gene ExpressionActive Transport, Cell NucleusAnimalsChromatinHumansNuclear PoreNuclear Pore Complex ProteinsTranscription, GeneticChromatinNuclear Pore Complex Proteins

Identifiers

PMID24657998
PMCPMC4061258
OpenAlexW1983135362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.