ArticleEnvironmental research2014
The level of submicron fungal fragments in homes with asthmatic children.
Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Using Sensor Data to Identify Factors Affecting Internal Air Quality within 279 Lower Income Households in Cornwall, South West of England.International journal of environmental research and public health · 2023Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study.BMC microbiology · 2020Article
- Fungal aerosol composition in moldy basements.Indoor air · 2019Article
- Fungal Fragments and Fungal Aerosol Composition in Sawmills.Annals of work exposures and health · 2018Article
- Fungal Exposure and Asthma: IgE and Non-IgE-Mediated Mechanisms.Current allergy and asthma reports · 2016Review
- Does Specific Fungal Allergen Really Matter?Allergy, asthma & immunology research · 2016Article
- Indoor Fungal Exposure and Allergic Respiratory Disease.Current allergy and asthma reports · 2015Review
- Indirect Immunodetection of Fungal Fragments by Field Emission Scanning Electron Microscopy.Applied and environmental microbiology · 2015Article
- Submicronic fungal bioaerosols: high-resolution microscopic characterization and quantification.Applied and environmental microbiology · 2014Article
- Cultivation and aerosolization ofInhalation toxicologyArticle
- Profile and Morphology of Fungal Aerosols Characterized by Field Emission Scanning Electron Microscopy (FESEM).Aerosol science and technology : the journal of the American Association for Aerosol ResearchArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesMuch scientific evidence indicates a positive association between moldy environments and respiratory illnesses and/or symptoms (e.g., asthma). Recently, submicron fungal fragments (<1.0 μm) have been suggested as a potential contributor to adverse health effects due to their biological composition (e.g., antigens, mycotoxins, and (1,3)-β-D-glucan) as well as their small size. However, the contribution of exposure to fine fungal particles on adverse health outcomes has been poorly characterized, particularly in homes with asthmatic children. We characterized the airborne level of smaller-sized fungal particles between homes with and without asthmatic children.
methodsWe visited 29 homes with (n=15) and without (n=14) an asthmatic child and sampled submicron fungal fragments in a living room and child׳s bedroom, along with outdoor sampling, using the NIOSH two-stage sampler. (1,3)-β-D-glucan of fungal fragments analyzed by Limulus Amebocyte lysate assay (LAL) was used for quantifying their exposure.
resultsOverall, the geometric mean (GM) concentration of (1,3)-β-D-glucan in submicron fungal fragments in indoor air was two-fold higher in homes with asthmatic children (50.9 pg/m(3)) compared to homes with non-asthmatic children (26.7 pg/m(3)) (P<0.001). The GM concentration of these particles in child׳s bedroom in homes with an asthmatic child (66.1 pg/m(3)) was about three times higher than that in homes with non-asthmatic children (23.0 pg/m(3)) (P<0.001). The relative humidity had a negative correlation with the concentration of (1,3)-β-D-glucan in submicron fungal fragments (Pearson coefficient=-0.257, P=0.046).
conclusionsOur findings indicate that homes with asthmatic children have a higher concentration of submicron fungal fragments compared to homes with non-asthmatic children. A greater exposure to smaller-sized fungal particles may occur in homes with an asthmatic child as relative humidity decreases. The very careful control of relative humidity in indoor air is necessary for reducing exposure to fine fungal particles and inhibiting the growth of microorganisms in homes with allergic diseases.
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