ArticleApplied and environmental microbiology2014
Analysis of hydroxycinnamic acid degradation in Agrobacterium fabrum reveals a coenzyme A-dependent, beta-oxidative deacetylation pathway.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Microbial Lignin Valorization to Protocatechuic Acid and Catechol: Biofunneling Pathways and Metabolic Engineering Strategies.Biomolecules · 2026Review
- The introduction of a fungus-originated lip H8 confers higher gene transformation efficiency of Agrobacterium fabrum in Nicotiana benthamiana.World journal of microbiology & biotechnology · 2026Article
- A Dual-Receptor System MediatesJournal of agricultural and food chemistry · 2026Article
- A new amidohydrolase and β-oxidation-like pathway for piperine catabolism in soil actinomycetes.The Journal of biological chemistry · 2025Article
- A comprehensive review on microbial production of vanillin: metabolic engineering strategies and pathway-specific yields across microbial hosts.Archives of microbiology · 2025Review
- Hidden diversity inMicrobiology spectrum · 2025Article
- MarR Family Transcriptional Regulators and Their Roles in Plant-Interacting Bacteria.Microorganisms · 2023Review
- Glucose-Derived Raspberry Ketone Produced via EngineeredFrontiers in bioengineering and biotechnology · 2022Article
- Characterization of the first tetrameric transcription factor of the GntR superfamily with allosteric regulation from the bacterial pathogen Agrobacterium fabrum.Nucleic acids research · 2021Article
- Contribution of Berry Polyphenols to the Human Metabolome.Molecules (Basel, Switzerland) · 2019Review
- Ecological Conditions and Molecular Determinants Involved inFrontiers in plant science · 2019Review
- Functional Redundancy in the Hydroxycinnamate Catabolism Pathways of the Salt Marsh Bacterium Sagittula stellata E-37.Applied and environmental microbiology · 2018Article
- Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin.Applied and environmental microbiology · 2018Article
- Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization.Biotechnology for biofuels · 2018Article
- Ancestral Genome Estimation Reveals the History of Ecological Diversification in Agrobacterium.Genome biology and evolution · 2017Article
- Pseudomonas putida F1 uses energy taxis to sense hydroxycinnamic acids.Microbiology (Reading, England) · 2017Article
- Development of an Improved System for the Generation of Knockout Mutants of Amycolatopsis sp. Strain ATCC 39116.Applied and environmental microbiology · 2017Article
- Genomic characterization of Ensifer aridi, a proposed new species of nitrogen-fixing rhizobium recovered from Asian, African and American deserts.BMC genomics · 2017Article
- Coordinated Regulation of Species-Specific Hydroxycinnamic Acid Degradation and Siderophore Biosynthesis Pathways in Agrobacterium fabrum.Applied and environmental microbiology · 2016Article
- Metabolic Engineering of the Actinomycete Amycolatopsis sp. Strain ATCC 39116 towards Enhanced Production of Natural Vanillin.Applied and environmental microbiology · 2016Article
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Authors and funding
12 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The soil- and rhizosphere-inhabiting bacterium Agrobacterium fabrum (genomospecies G8 of the Agrobacterium tumefaciens species complex) is known to have species-specific genes involved in ferulic acid degradation. Here, we characterized, by genetic and analytical means, intermediates of degradation as feruloyl coenzyme A (feruloyl-CoA), 4-hydroxy-3-methoxyphenyl-β-hydroxypropionyl-CoA, 4-hydroxy-3-methoxyphenyl-β-ketopropionyl-CoA, vanillic acid, and protocatechuic acid. The genes atu1416, atu1417, and atu1420 have been experimentally shown to be necessary for the degradation of ferulic acid. Moreover, the genes atu1415 and atu1421 have been experimentally demonstrated to be essential for this degradation and are proposed to encode a phenylhydroxypropionyl-CoA dehydrogenase and a 4-hydroxy-3-methoxyphenyl-β-ketopropionic acid (HMPKP)-CoA β-keto-thiolase, respectively. We thus demonstrated that the A. fabrum hydroxycinnamic degradation pathway is an original coenzyme A-dependent β-oxidative deacetylation that could also transform p-coumaric and caffeic acids. Finally, we showed that this pathway enables the metabolism of toxic compounds from plants and their use for growth, likely providing the species an ecological advantage in hydroxycinnamic-rich environments, such as plant roots or decaying plant materials.
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