ArticleCirculation. Cardiovascular imaging2014
Near-infrared II fluorescence for imaging hindlimb vessel regeneration with dynamic tissue perfusion measurement.
Article in Circulation. Cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 94 citations in OpenAlex.
- Short-wave infrared (SWIR) spectroscopy and imaging of biological tissues: a decade of advancements (2016-2025).Journal of biomedical optics · 2026Review
- Nanoparticle Detection in Biology and Medicine: A Review.Biosensors · 2025Review
- Short-wave infrared fluorescence imaging of near-infrared dyes with robust end-tail emission using a small-animal imaging device.PNAS nexus · 2023Article
- Shortwave infrared fluorescence imaging of peripheral organs in awake and freely moving mice.Frontiers in neuroscience · 2023Article
- Quantifying multiple stain distributions in bioimaging by hyperspectral X-ray tomography.Scientific reports · 2022Article
- Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance.Nature communications · 2022Article
- Article
- Polyglutamate-based nanoconjugates for image-guided surgery and post-operative melanoma metastases prevention.Theranostics · 2022Article
- Noninvasive and early diagnosis of acquired brain injury using fluorescence imaging in the NIR-II window.Biomedical optics express · 2021Article
- The Advance of CRISPR-Cas9-Based and NIR/CRISPR-Cas9-Based Imaging System.Frontiers in chemistry · 2021Review
- Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm.Theranostics · 2021Article
- Vascularization in tissue engineering: fundamentals and state-of-art.Progress in biomedical engineering (Bristol, England) · 2020Article
- Automated in vivo Assessment of Vascular Response to Radiation using a Hybrid Theranostic X-ray Irradiator/Fluorescence Molecular Imaging System.IEEE access : practical innovations, open solutions · 2020Article
- Near-Infrared IIb Fluorescence Imaging of Vascular Regeneration with Dynamic Tissue Perfusion Measurement and High Spatial Resolution.Advanced functional materials · 2018Article
- Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging.Chemical science · 2018Review
- Near-Infrared Fluorescence Imaging Directly Visualizes Lymphatic Drainage Pathways and Connections between Superficial and Deep Lymphatic Systems in the Mouse Hindlimb.Scientific reports · 2018Article
- A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues.Nature communications · 2018Article
- Protein-engineered hydrogels enhance the survival of induced pluripotent stem cell-derived endothelial cells for treatment of peripheral arterial disease.Biomaterials science · 2018Article
- Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy.Theranostics · 2018Article
- Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins.Theranostics · 2018Article
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12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundReal-time vascular imaging that provides both anatomic and hemodynamic information could greatly facilitate the diagnosis of vascular diseases and provide accurate assessment of therapeutic effects. Here, we have developed a novel fluorescence-based all-optical method, named near-infrared II (NIR-II) fluorescence imaging, to image murine hindlimb vasculature and blood flow in an experimental model of peripheral arterial disease, by exploiting fluorescence in the NIR-II region (1000-1400 nm) of photon wavelengths. METHODS AND
resultsBecause of the reduced photon scattering of NIR-II fluorescence compared with traditional NIR fluorescence imaging and thus much deeper penetration depth into the body, we demonstrated that the mouse hindlimb vasculature could be imaged with higher spatial resolution than in vivo microscopic computed tomography. Furthermore, imaging during 26 days revealed a significant increase in hindlimb microvascular density in response to experimentally induced ischemia within the first 8 days of the surgery (P<0.005), which was confirmed by histological analysis of microvascular density. Moreover, the tissue perfusion in the ischemic hindlimb could be quantitatively measured by the dynamic NIR-II method, revealing the temporal kinetics of blood flow recovery that resembled microbead-based blood flowmetry and laser Doppler blood spectroscopy.
conclusionsThe penetration depth of millimeters, high spatial resolution, and fast acquisition rate of NIR-II imaging make it a useful imaging tool for murine models of vascular disease.
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