Evidence map›Paper›PMID 24656850›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014

Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery.

Melissa Mathews, Erin Abner, Richard Kryscio, Gregory Jicha, Gregory Cooper, Charles Smith, Allison Caban-Holt, Frederick A Schmitt

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
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  8. Models of depressive pseudoamnestic disorder.Alzheimer's & dementia (New York, N. Y.) · 2022
    Article
  9. Article
  10. Article
  11. Reliable change in cognition over 1 week in community-dwelling older adults: a validation and extension study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021
    Article
  12. Cognitive Practice Effects Delay Diagnosis; Implications for Clinical Trials.medRxiv : the preprint server for health sciences · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
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  19. Article
  20. Incident Antipsychotic Use in a Diverse Population with Dementia.Journal of the American Geriatrics Society · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melissa MathewsSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
Erin AbnerSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Statistics and Biostatistics, University of Kentucky, Lexington, KY, USA.
Richard KryscioSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Statistics and Biostatistics, University of Kentucky, Lexington, KY, USA.
Gregory JichaSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
Gregory CooperSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Baptist Neurology Center, University of Kentucky, Lexington, KY, USA.
Charles SmithSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.
Allison Caban-HoltSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA.
Frederick A SchmittSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA. Electronic address: fascom@uky.edu.

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI SCHMITT, FREDERICK · 2006 to 2020
$23.3M
Prevention of Alzheimer's Diseae by Vitamin E and SeleniumR01AG019241 · NIA · UNIVERSITY OF KENTUCKY · PI SCHMITT, FREDERICK · 2001 to 2012
$12.1M
Role of impaired cognitive states & risk factors in conversion to mixed dementiasR01AG038651 · NIA · UNIVERSITY OF KENTUCKY · PI ABNER, ERIN, KRYSCIO, RICHARD J. · 2011 to 2023
$6.1M
NIA NIH HHS P30 AG028383NIA NIH HHS P30AG028383NIA NIH HHS R01 AG019241NIA NIH HHS R01AG019241NIA NIH HHS R01 AG038651NIA NIH HHS R01AG038651NIA NIH HHS U01 AG016976
6 · The paper itself

Abstract

introductionThe Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.

methodsA normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups.

resultsThe total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test-exposed participants were significantly higher than test-naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group.

conclusionThe total score's classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.

Indexed as

Neuropsychological TestsAgedAged, 80 and overAlzheimer DiseaseCognition DisordersData CollectionFemaleHumansMaleMemory DisordersMiddle AgedReference ValuesRegression AnalysisUnited StatesAgingCognitive testingDiagnostic accuracyLongitudinal dataPractice effects

Identifiers

PMID24656850
PMCPMC4169759

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.