ArticleCell reports2014
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 121 citations in OpenAlex.
- Preterm birth disrupts nephron progenitor cell dynamics predisposing to renal disease.iScience · 2026Article
- Epigenetic regulation of nephrogenesis: from Waddington's landscape to adult disease.American journal of physiology. Renal physiology · 2026Review
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- Developmentally inspired synthetic kidney engineering.Nature biotechnology · 2026Review
- Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population.Development (Cambridge, England) · 2026Article
- Cystic fibrosis-related kidney disease-emerging morbidity and disease modifier.Pediatric nephrology (Berlin, Germany) · 2025Review
- Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.The EMBO journal · 2025Article
- Engineering kidney developmental trajectory using culture boundary conditions.Nature communications · 2025Article
- Absent, Small, or Homeotic 2-Like-Mediated H3K4 Methylation and Nephrogenesis.Journal of the American Society of Nephrology : JASN · 2025Article
- Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model.American journal of physiology. Renal physiology · 2025Article
- Article
- Jamming of nephron-forming niches in the developing mouse kidney creates cyclical mechanical stresses.Nature materials · 2024Article
- Highly parallel production of designer organoids by mosaic patterning of progenitors.Cell systems · 2024Article
- Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease.American journal of physiology. Renal physiology · 2024Review
- Article
- The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy.International journal of molecular sciences · 2024Review
- Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors.bioRxiv : the preprint server for biology · 2024Article
- Electrophysiological Properties of Proprioception-Related Neurons in the Intermediate Thoracolumbar Spinal Cord.eNeuro · 2024Article
- Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions.Frontiers in microbiology · 2024Review
- The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.Developmental cell · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme [CM]) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. Although low nephron number is implicated in hypertension and renal disease, the mechanisms that determine nephron number are obscure. To test the importance of nephron progenitor cell number, we genetically ablated 40% of these cells, asking whether this would limit kidney size and nephron number or whether compensatory mechanisms would allow the developing organ to recover. The reduction in CM cell number decreased the rate of branching, which in turn allowed the number of CM cells per UB tip to normalize, revealing a self-correction mechanism. However, the retarded UB branching impaired kidney growth, leaving a permanent nephron deficit. Thus, the number of fetal nephron progenitor cells is an important determinant of nephron endowment, largely via its effect on UB branching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.