ReviewChild and adolescent psychiatric clinics of North America2014
The biological effects of childhood trauma.
Review in Child and adolescent psychiatric clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
263 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Early childhood trauma and its long-term impact on cognitive and emotional development: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Increased Prevalence of Childhood Complex Trauma in Comorbid Posttraumatic Stress Disorder and Substance Use Disorders Compared to Either Disorder Alone: A Systematic Review.Early intervention in psychiatry · 2025Pooled it
- The relationship between childhood interpersonal and non-interpersonal trauma and autobiographical memory: a systematic review.Frontiers in psychology · 2024Pooled it
- The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review.Journal of the American Heart Association · 2023Pooled it
- Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.Brain connectivity · 2023Pooled it
- The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis.Journal of affective disorders · 2019Pooled it
- Pooled it
- Trial
- Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial.Translational psychiatry · 2025Trial
- The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study.BMC complementary medicine and therapies · 2021Trial
- Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms.European archives of psychiatry and clinical neuroscience · 2019Trial
- The relationship between age of first exposure and posttraumatic symptoms: results from the global psychotrauma screen.European journal of psychotraumatology · 2026Article
- Building the framework for ongoing discovery: coding practice elements in child traumatic stress intervention studies.European journal of psychotraumatology · 2026Article
- Proteomic insights into childhood adversity: Exploring biological mechanisms and cognitive outcomes in the CARDIA study.Brain, behavior, & immunity - health · 2026Article
- Article
- Positive association between sex hormones and inflammatory cytokines in trauma-exposed premenopausal women.Brain, behavior, & immunity - health · 2026Article
- Childhood Trauma and Frontoparietal Network Connectivity During Working Memory Task Performance in Individuals With Schizophrenia and Healthy Participants.The European journal of neuroscience · 2026Article
- Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits.Journal of adolescence · 2026Article
- Childhood Trauma and Adult Loneliness as Predictors of Sleep Health in Blackfeet American Indian Adults.International journal of behavioral medicine · 2026Article
203 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Trauma in childhood is a psychosocial, medical, and public policy problem with serious consequences for its victims and for society. Chronic interpersonal violence in children is common worldwide. Developmental traumatology, the systemic investigation of the psychiatric and psychobiological effects of chronic overwhelming stress on the developing child, provides a framework and principles when empirically examining the neurobiological effects of pediatric trauma. This article focuses on peer-reviewed literature on the neurobiological sequelae of childhood trauma in children and in adults with histories of childhood trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.