ArticleAutonomic neuroscience : basic & clinical2014
Dexmedetomidine and regulation of splenic sympathetic nerve discharge.
Article in Autonomic neuroscience : basic & clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Ultrasound-guided dexmedetomidine combination with modified high fascia iliaca compartment block for arthroscopic knee surgery: what is the optimal dose of dexmedetomidine?BMC anesthesiology · 2023Trial
- Efficacy of Intranasal Dexmedetomidine Premedication as an Adjunct on Intubation Process in Paediatric Patients: A Randomized, Double-blind, Placebo-controlled Trial.Turkish journal of anaesthesiology and reanimation · 2026Article
- Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy.Experimental physiology · 2026Article
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Evaluation of the Adjuvant Effect of Dexmedetomidine on Ropivacaine for Transversus Abdominis Plane Block in Inguinal Hernia Repair: A Prospective Double-Blind Randomized Trial.Journal of clinical medicine · 2025Article
- Central αThe Journal of physiology · 2024Article
- Centrally Projecting Edinger-Westphal Nucleus in the Control of Sympathetic Outflow and Energy Homeostasis.Brain sciences · 2021Review
- Neurologic Assessment of the Neurocritical Care Patient.Frontiers in neurology · 2021Review
- Mechanisms of Dexmedetomidine in Neuropathic Pain.Frontiers in neuroscience · 2020Review
- Dexmedetomidine and regulation of splenic sympathetic nerve discharge in aged F344 rats.Autonomic neuroscience : basic & clinical · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent lines of inquiry indicate that sedatives can influence the immune system, leading to the concept of sedative-induced immunomodulation. It has been hypothesized that sedatives may alter immune responses by modulating the sympathetic nervous system, however, little information is known regarding the effects of sedatives on regulation of splenic sympathetic nerve discharge (SND), a significant omission based on the functional role that changes in splenic SND exert on splenic cytokine gene expression. The present investigation determined the effect of systemic Dexmedetomidine (Dex) administration on the level of directly-recorded splenic SND and tested the hypothesis that the intravenous administration of Dex would inhibit splenic SND in anesthetized rats. The present results demonstrate for the first time that intravenous Dex administration significantly reduces splenic sympathetic nerve outflow in baroreceptor-intact and sinoaortic-denervated rats, indicating that Dex administration alters the central regulation of splenic SND. The present results provide new information regarding the effect of a centrally-acting alpha2-adrenergic agonist on the level of sympathetic nerve outflow to a secondary lymphoid organ that plays a critical role in peripheral immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.