ArticleNeuron2014
Dorsal raphe neurons signal reward through 5-HT and glutamate.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 276 papers.
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Who cites it
276 citing papers in PubMed.
- A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss.Journal of psychiatry & neuroscience : JPN · 2021Trial
- Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals.Molecular psychiatry · 2020Trial
- Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone.Psychological medicine · 2019Trial
- Effects of SSRIs on the spatial transcriptome of dorsal raphe serotonin neurons.Molecular psychiatry · 2026Article
- Cellular and molecular coding of habit-driven behavior in the dorsal raphe nucleus.bioRxiv : the preprint server for biology · 2026Article
- Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- SCTR-Expressing Astrocyte-Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac-Foxc2 Epigenetic Axis in an AMPK-Dependent Manner.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Psychopharmacological Mechanisms of Antidepressant Withdrawal: Insights From Venlafaxine.Human psychopharmacology · 2026Review
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- Economic and social modulations of innate decision-making in mice exposed to visual threats.eLife · 2026Article
- Phenotypic Behavioural Effects of Genetic Deletion of the Vesicular Glutamate Transporter 3 in 5-Hydroxytryptamine Neurons.Genes, brain, and behavior · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Selectively Labeling and Distinguishing Adrenergic and Noradrenergic Neurons in the Sympathetic Nervous System.Neuroscience bulletin · 2026Article
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Transcranial magneto-acoustic stimulation improves corticostriatal transmission in direct medium spiny neurons and rescues neuroplasticity of Parkinson's disease model mice.NPJ Parkinson's disease · 2026Article
- Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans.Nature communications · 2026Article
- A dopaminergic projection from the ventral tegmental area to the dorsal raphe nucleus critically regulates propofol anesthesia in mice.Biology direct · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
216 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-hydroxytryptamine; 5-HT)-expressing neurons. Serotonergic neurons in the DRN have been theorized to encode punishment by opposing the reward signaling of dopamine neurons. Here, we show that DRN neurons encode reward, but not punishment, through 5-HT and glutamate. Optogenetic stimulation of DRN Pet-1 neurons reinforces mice to explore the stimulation-coupled spatial region, shifts sucrose preference, drives optical self-stimulation, and directs sensory discrimination learning. DRN Pet-1 neurons increase their firing activity during reward tasks, and this activation can be used to rapidly change neuronal activity patterns in the cortex. Although DRN Pet-1 neurons are often associated with 5-HT, they also release glutamate, and both neurotransmitters contribute to reward signaling. These experiments demonstrate the ability of DRN neurons to organize reward behaviors and might provide insights into the underlying mechanisms of learning facilitation and anhedonia treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.