ArticleNeuron2014
Synaptically induced long-term modulation of electrical coupling in the inferior olive.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.The Journal of physiology · 2026Article
- Association of connexin36 with adherens junctions at mixed synapses and distinguishing electrophysiological features of those at mossy fiber terminals in rat ventral hippocampus.International journal of physiology, pathophysiology and pharmacology · 2024Article
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- Time and tide of cerebellar synchrony.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- GABAInternational journal of molecular sciences · 2021Article
- Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Diversity and dynamism in the cerebellum.Nature neuroscience · 2021Review
- NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans.Nature communications · 2020Article
- Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.PLoS computational biology · 2020Article
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Article
- Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy.International journal of molecular sciences · 2019Review
- Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.Nature neuroscience · 2019Article
- Quasiperiodic rhythms of the inferior olive.PLoS computational biology · 2019Article
- Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control.The Journal of physiology · 2019Article
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3 authors at 1 institution in 1 country.
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Abstract
Electrical coupling mediated by gap junctions is widespread in the mammalian CNS, and the interplay between chemical and electrical synapses on the millisecond timescale is crucial for determining patterns of synchrony in many neural circuits. Here we show that activation of glutamatergic synapses drives long-term depression of electrical coupling between neurons of the inferior olive. We demonstrate that this plasticity is not triggered by postsynaptic spiking alone and that it requires calcium entry following synaptic NMDA receptor activation. These results reveal that glutamatergic synapses can instruct plasticity at electrical synapses, providing a means for excitatory inputs to homeostatically regulate the long-term dynamics of microzones in olivocerebellar circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.