Evidence map›Paper›PMID 24656077›Full record

ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2014

Sensitivity enhancement in solution NMR: emerging ideas and new frontiers.

Jung Ho Lee, Yusuke Okuno, Silvia Cavagnero

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Nuclear-Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra-High Field.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2026
    Article
  2. Review
  3. Article
  4. Computational and Experimental Approaches and Applications of Biological NMR.Advances in experimental medicine and biology · 2026
    Review
  5. Review
  6. Continuous-Wave (CW) Photo-CIDNP NMR Spectroscopy: A Tutorial.Magnetic resonance in chemistry : MRC · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. RadicalPy: A Tool for Spin Dynamics Simulations.Journal of chemical theory and computation · 2024
    Article
  11. HyperpolarizedMolecules (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jung Ho LeeDepartment of Chemistry and Biophysics Program, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1322, USA.
Yusuke OkunoDepartment of Chemistry and Biophysics Program, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1322, USA.
Silvia CavagneroDepartment of Chemistry and Biophysics Program, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1322, USA. Electronic address: cavagnero@chem.wisc.edu.

Funding

PREDOCTORAL TRAINING IN MOLECULAR BIOPHYSICST32GM008293 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B. · 1989 to 2016
$4.6M
Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
Development of Laser-Mediated Hyper-Sensitive NMR in LiquidsR21GM111611 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2014 to 2016
$519k
Ultra-sensitive NMR via Photochemically induced dynamic nuclear polarizationR21AI088551 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2010 to 2011
$341k
NEISSERIA MENINGITIDIS GROUP B;IDIOTYPES AND VACCINESF33AI008851 · NIAID · CHILDREN'S HOSPITAL &RES CTR AT OAKLAND · PI GRANOFF, DAN M. · 1992 to 1992
–
NIAID NIH HHS R21AI08851NIAID NIH HHS R21 AI088551NIGMS NIH HHS R21 GM111611NIGMS NIH HHS T32 GM008293NIH HHS S10 OD012245
6 · The paper itself

Abstract

Modern NMR spectroscopy has reached an unprecedented level of sophistication in the determination of biomolecular structure and dynamics at atomic resolution in liquids. However, the sensitivity of this technique is still too low to solve a variety of cutting-edge biological problems in solution, especially those that involve viscous samples, very large biomolecules or aggregation-prone systems that need to be kept at low concentration. Despite the challenges, a variety of efforts have been carried out over the years to increase sensitivity of NMR spectroscopy in liquids. This review discusses basic concepts, recent developments and future opportunities in this exciting area of research.

Indexed as

AlgorithmsAnimalsHumansHydrogenIndicators and ReagentsModels, MolecularMolecular ConformationNuclear Magnetic Resonance, BiomolecularPhotochemistryTemperatureHydrogenIndicators and ReagentsDissolution DNPFast NMRHyperpolarizationNMR sensitivityOverhauser DNPPHIPPhoto-CIDNPSEOP

Identifiers

PMID24656077
PMCPMC3967054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.