ArticleEmerging infectious diseases2014
Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia.
Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 171 citations in OpenAlex.
- Immunological insights into why pertussis continues to be endemic.Human vaccines & immunotherapeutics · 2026Review
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- Breakthrough infections and incomplete vaccine efficacy drive pathogen immune escape.PloS one · 2026Article
- Sharp rise in high-virulence Bordetella pertussis with macrolides resistance in Northern China.Emerging microbes & infections · 2025Article
- Genomic epidemiology and evolution ofEmerging microbes & infections · 2025Article
- Resurgence of pertussis: whopping the '100-day cough'.Current opinion in pediatrics · 2025Review
- Vaccine antigen-based genotyping ofMicrobiology spectrum · 2025Article
- Harnessing outer membrane vesicles derived fromFrontiers in immunology · 2025Article
- Epidemiological characteristics and survival analysis of pertussis in Quzhou.Human vaccines & immunotherapeutics · 2024Article
- DecipheringJournal of clinical microbiology · 2024Article
- Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model.Vaccines · 2024Article
- Screening of Novel Drug Targets and Drug Design forCurrent research in microbial sciences · 2024Article
- [Pertussis worldwide. Vaccinating children and adults].Medecine tropicale et sante internationale · 2023Article
- Genomic epidemiology and multilevel genome typing ofEmerging microbes & infections · 2023Article
- The Present and Future Aspects of Life-Long Pertussis Prevention: Narrative Review with Regional Perspectives for Türkiye.Infectious diseases and therapy · 2023Review
- Whole-Genome Analysis of Bordetella pertussis MT27 Isolates from School-Associated Outbreaks: Single-Nucleotide Polymorphism Diversity and Threshold of the Outbreak Strains.Microbiology spectrum · 2023Article
- Review
- Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.Journal of clinical microbiology · 2023Article
- Antigen Discovery for Next-Generation Pertussis Vaccines Using Immunoproteomics and Transposon-Directed Insertion Sequencing.The Journal of infectious diseases · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms of Prn inactivation were documented, including IS481 and IS1002 disruptions, a variation within a homopolymeric tract, and deletion of the prn gene. The mechanism of lack of expression of Prn in 16 (17%) isolates could not be determined at the sequence level. These findings suggest that B. pertussis not expressing Prn arose independently multiple times since 2008, rather than by expansion of a single Prn-negative clone. All but 1 isolate had ptxA1, prn2, and ptxP3, the alleles representative of currently circulating strains in Australia. This pattern is consistent with continuing evolution of B. pertussis in response to vaccine selection pressure.
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Registered trials
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