ArticleJournal of vascular surgery2015
Patterns of chronic venous insufficiency in the dural sinuses and extracranial draining veins and their relationship with white matter hyperintensities for patients with Parkinson's disease.
Article in Journal of vascular surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Safety and efficacy of venoplasty in MS: A randomized, double-blind, sham-controlled phase II trial.Neurology · 2018Trial
- Characterization of Arterial and Sinus Blood Flow Dynamics in the Rat Brain Using Phase-Contrast MRI.Annals of biomedical engineering · 2026Article
- Association between varicose veins and occurrence of dementia: A nationwide population-based cohort study.PloS one · 2025Article
- Revisiting Virchow's triad: exploring the cellular and molecular alterations in cerebral venous congestion.Cell & bioscience · 2024Article
- Nonarteritic anterior ischemic optic neuropathy and incidence of Parkinson's disease based on a nationwide population based study.Scientific reports · 2024Article
- Cerebrospinal fluid dynamics coupled to the global circulation in holistic setting: Mathematical models, numerical methods and applications.International journal for numerical methods in biomedical engineering · 2022Article
- Pathogenesis and Management in Cerebrovenous Outflow Disorders.Aging and disease · 2021Review
- Use of patient-reported data in determining factors contributing to internal jugular vein stenosis outcomes.Annals of translational medicine · 2020Article
- Anatomical Morphology Analysis of Internal Jugular Veins and Factors Affecting Internal Jugular Vein Size.Medicina (Kaunas, Lithuania) · 2020Article
- Clinical characteristics and neuroimaging findings in eagle syndrome induced internal jugular vein stenosis.Annals of translational medicine · 2020Article
- Clinical Classification and Collateral Circulation in Chronic Cerebrospinal Venous Insufficiency.Frontiers in neurology · 2020Article
- Probable factors affecting clinical outcomes of internal jugular vein stenosis.Annals of translational medicine · 2019Article
- Susceptibility mapping of the dural sinuses and other superficial veins in the brain.Magnetic resonance imaging · 2019Article
- Jugular Venous Flow Quantification Using Doppler Sonography.Ultrasound in medicine & biology · 2018Article
- Understanding jugular venous outflow disturbance.CNS neuroscience & therapeutics · 2018Review
- Aging of cerebral white matter.Ageing research reviews · 2017Review
- Ultrasound diagnosis of transverse sinus hypoplasia using flow profiles of the internal jugular vein.PloS one · 2017Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIdiopathic Parkinson's disease (IPD) remains one of those neurodegenerative diseases for which the cause remains unknown. Many clinically diagnosed cases of IPD are associated with cerebrovascular disease and white matter hyperintensities (WMHs). The purpose of this study was to investigate the presence of transverse sinus and extracranial venous abnormalities in IPD patients and their relationship with brain WMHs.
methodsTwenty-three IPD patients and 23 age-matched normal controls were recruited in this study. They had conventional neurologic magnetic resonance structural and angiographic scans and, for blood flow, quantification of the extracranial vessels. Venous structures were evaluated with two-dimensional time of flight; flow was evaluated with two-dimensional phase contrast; and WMH volume was quantified with T2-weighted fluid-attenuated inversion recovery. The IPD and normal subjects were classified by both the magnetic resonance time-of-flight and phase contrast images into four categories: (1) complete or local missing transverse sinus and internal jugular veins on the time-of-flight images; (2) low flow in the transverse sinus and stenotic internal jugular veins; (3) reduced flow in the internal jugular veins; and (4) normal flow and no stenosis.
resultsBroken into the four categories with categories 1 to 3 combined, a significant difference in the distribution of the IPD patients and normal controls (χ(2) = 7.7; P < .01) was observed. Venous abnormalities (categories 1, 2, and 3) were seen in 57% of IPD subjects and in only 30% of controls. In IPD subjects, category type correlated with both flow abnormalities and WMHs.
conclusionsFrom this preliminary study, we conclude that a major fraction of IPD patients appear to have abnormal venous anatomy and flow on the left side of the brain and neck and that the flow abnormalities appear to correlate with WMH volume. Studies with a larger sample size are still needed to confirm these findings.
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