ArticleBMC neurology2014
CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population.
Article in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Cellular and molecular neurobiology · 2023Review
- Genetics behind Cerebral Disease with Ocular Comorbidity: Finding Parallels between the Brain and Eye Molecular Pathology.International journal of molecular sciences · 2022Review
- BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder.CNS neuroscience & therapeutics · 2021Article
- A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder.Frontiers in immunology · 2021Review
- Interaction of HLA Class II rs9272219 andFrontiers in genetics · 2021Article
- CD58 Immunobiology at a Glance.Frontiers in immunology · 2021Review
- Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.Scientific reports · 2020Article
- Association ofAuto- immunity highlights · 2019Article
- A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene.PLoS genetics · 2019Article
- Association ofNeural regeneration research · 2019Article
- Pediatric Neuromyelitis Optica Spectrum Disorders.Current treatment options in neurology · 2018Review
- Association of Optic Neuritis withJournal of ophthalmology · 2018Article
- STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders.Neuromolecular medicine · 2017Article
- Association of TNFSF4 Polymorphisms with Neuromyelitis Optica Spectrum Disorders in a Chinese Population.Journal of molecular neuroscience : MN · 2017Article
- Association of CD40 Gene Polymorphisms with Susceptibility to Neuromyelitis Optica Spectrum Disorders.Molecular neurobiology · 2017Article
- Immunopathogenesis in Myasthenia Gravis and Neuromyelitis Optica.Frontiers in immunology · 2017Review
- Roles of CD48 in regulating immunity and tolerance.Clinical immunology (Orlando, Fla.) · 2016Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuromyelitis optica (NMO) is a serious inflammatory demyelinating disease (IDD), characterized by the inflammation and demyelination of optic nerves and spinal cords, which subsequently leads to the loss of function. In a previous genome-wide association study, cluster of differentiation 58 (CD58) region was found to be susceptible for the risk of multiple sclerosis (MS) in Caucasian, and the association between CD58 variants and MS was replicated in Americans. However, no study has been conducted to explore the possible association between CD58 and NMO yet. Thus, this study aimed to investigate the association of CD58 polymorphisms with the risk of NMO in a Korean population.
methodsUsing TaqMan assay, 6 single nucleotide polymorphisms (SNPs) were genotyped in 98 NMO patients and 237 normal controls (N = 336). Logistic regression analysis was conducted to find a possible association between CD58 polymorphisms and NMO.
resultsThe analysis results showed that 6 variations (rs2300747, rs1335532, rs12044852, rs1016140, CD58_ht1, and CD58_ht3) showed significant associations (P = 0.002 ~ 0.008, P(corr) = 0.01 ~ 0.04).
conclusionThe genetic variations in CD58 may be associated with the susceptibility of NMO in a Korean population. Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk. Also, we deduced that the G allele of rs1016140 caused an increase of T cell activity, which in turn eased the access of AQP4 antibody into central nervous system (CNS) and ultimately leading to NMO development.
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